Human immunodeficiency virus type 1 (HIV-1), a lentivirus that causes acquired
immunodeficiency syndrome (AIDS), poses a serious threat to global public health. Since …

Abstract HIV-1 integrase (IN) enzyme, one of the three main enzymes of HIV-1, catalyzed the
insertion of the viral DNA into the genome of host cells. Because of the lack of its homologue …

Quinoline and its derivatives are widely studied by both synthetic and computational
chemists due to their exciting perspectives in biological and nonlinear optical (NLO) …

HIV-1 integrase (IN) is a validated therapeutic target for antiviral drug design. However, the
emergence of viral strains resistant to clinically studied IN inhibitors demands the discovery …

Candida albicans, an opportunistic fungal pathogen, frequently colonizes immune-
compromised patients and causes mild to severe systemic reactions. Only few antifungal …

A series of ethyl 1-(substituted benzoyl)-5-methylpyrrolo [1, 2-a] quinoline-3-carboxylates 4a–
f and dimethyl 1-(substituted benzoyl)-5-methylpyrrolo [1, 2-a] quinoline-2, 3-dicarboxylates …

In order to design novel anti-HIV agents, pharmacophore modelling, virtual screening, 3D-
QSAR and molecular docking studies were performed. Pharmacophore model was …

Quinolones continue to receive significant attention owing to their diverse range of biological
activities. They provide an important scaffold in anticancer, antibacterial and antiviral drug …

Millions of deaths have been reported due to viral infections in medical history, and various
viral infections are mentioned as the main cause of death. Although different types of …

This research communication is toward the investigation of the antibacterial, antifungal and
antioxidant activities of the synthesized compounds 1-(4′-O-β-d-glucopyranosyloxy-2 …