Synaptic effects of palmitoylethanolamide in neurodegenerative disorders

M Assogna, F Di Lorenzo, A Martorana, G Koch - Biomolecules, 2022 - mdpi.com
Increasing evidence strongly supports the key role of neuroinflammation in the
pathophysiology of neurodegenerative diseases, such as Alzheimer's disease …

A Decades-Long Journey of Palmitoylethanolamide (PEA) for Chronic Neuropathic Pain Management: A Comprehensive Narrative Review

G Varrassi, M Rekatsina, MLG Leoni, M Cascella… - Pain and Therapy, 2024 - Springer
Palmitoylethanolamide (PEA) has been prescribed in neuropathic pain management for
over 20 years. This study aims to summarize what has been published on the topic in the …

[HTML][HTML] Metabolic reprogramming in inflammatory microglia indicates a potential way of targeting inflammation in Alzheimer's disease

M Sangineto, M Ciarnelli, T Cassano, A Radesco… - Redox biology, 2023 - Elsevier
Microglia activation drives the pro-inflammatory activity in the early stages of Alzheimer's
disease (AD). However, the mechanistic basis is elusive, and the hypothesis of targeting …

Co-ultramicronized palmitoylethanolamide/luteolin restores oligodendrocyte homeostasis via peroxisome proliferator-activated receptor-α in an in vitro model of …

R Facchinetti, M Valenza, C Gomiero, GF Mancini… - Biomedicines, 2022 - mdpi.com
Oligodendrocytes are cells fundamental for brain functions as they form the myelin sheath
and feed axons. They perform these critical functions thanks to the cooperation with other …

Novel drug treatments for pain in advanced cancer and serious illness: a focus on neuropathic pain and chemotherapy-induced peripheral neuropathy

MP Davis - Palliative Care and Social Practice, 2024 - journals.sagepub.com
Drugs that are commercially available but have novel mechanisms of action should be
explored as analgesics. This review will discuss haloperidol, miragabalin …

[HTML][HTML] Signature of paraoxonases in the altered redox homeostasis in Alzheimer's disease

S Beggiato, F Ferrara, A Romani, T Cassano… - Chemico-Biological …, 2024 - Elsevier
Abstract Paraoxonase (PON) enzymes (PON1, PON2 and PON3) exert antioxidant
properties through arylesterase, lactonase and paraoxonase activities. Increasing findings …

A decades-long journey of palmitoylethanolamide (PEA), as a cornerstone in chronic neuropathic pain management: a comprehensive narrative review

G Varrassi, A Paladini, C Corno, S Coaccioli, G Finco… - 2024 - preprints.org
Palmitoylethanolamide (PEA) has been prescribed for neuropathic pain for several years.
This study is mainly addressed to summarize what has been published on the topic in the …

[HTML][HTML] Blueberry Consumption Improves Cognitive Executive Control in Insulin-Resistant Adults

T Woosley - naturalhealthresearch.org
Written by Taylor Woosley, Staff Writer. 12-week supplementation with blueberry powder
(equivalent to 0.5 c of blueberries) resulted in significant improvement in lexical access and …

NMR in living systems

MJW Prior - 2023 - books.rsc.org
This chapter reviews studies published during the period of May 2022 to April 2023 that
have applied magnetic resonance spectroscopy to investigate processes occurring in living …