[PDF][PDF] Atherosclerosis: recent developments

JLM Björkegren, AJ Lusis - Cell, 2022 - cell.com
Atherosclerosis is an inflammatory disease of the large arteries that is the major cause of
cardiovascular disease (CVD) and stroke. Here, we review the current understanding of the …

Consideration of sex differences in design and reporting of experimental arterial pathology studies—statement from ATVB council

P Robinet, DM Milewicz, LA Cassis… - … , and vascular biology, 2018 - Am Heart Assoc
There are many differences in arterial diseases between men and women, including
prevalence, clinical manifestations, treatments, and prognosis. The new policy of the …

[HTML][HTML] Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines

C Gao, Q Huang, C Liu, CHT Kwong, L Yue… - Nature …, 2020 - nature.com
Vascular disease remains the leading cause of death and disability, the etiology of which
often involves atherosclerosis. The current treatment of atherosclerosis by pharmacotherapy …

Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production

M Orecchioni, K Kobiyama, H Winkels, Y Ghosheh… - Science, 2022 - science.org
Atherosclerosis is an inflammatory disease of the artery walls and involves immune cells
such as macrophages. Olfactory receptors (OLFRs) are G protein–coupled chemoreceptors …

Pathogenic Autoimmunity in Atherosclerosis Evolves From Initially Protective Apolipoprotein B100–Reactive CD4+ T-Regulatory Cells

D Wolf, T Gerhardt, H Winkels, NA Michel, AB Pramod… - Circulation, 2020 - Am Heart Assoc
Background: Throughout the inflammatory response that accompanies atherosclerosis,
autoreactive CD4+ T-helper cells accumulate in the atherosclerotic plaque. Apolipoprotein …

Age-associated mitochondrial dysfunction accelerates atherogenesis

DJ Tyrrell, MG Blin, J Song, SC Wood, M Zhang… - Circulation …, 2020 - Am Heart Assoc
Rationale: Aging is one of the strongest risk factors for atherosclerosis. Yet whether aging
increases the risk of atherosclerosis independently of chronic hyperlipidemia is not known …

[HTML][HTML] Suppressing the intestinal farnesoid X receptor/sphingomyelin phosphodiesterase 3 axis decreases atherosclerosis

Q Wu, L Sun, X Hu, X Wang, F Xu… - The Journal of …, 2021 - Am Soc Clin Investig
Intestinal farnesoid X receptor (FXR) signaling is involved in the development of obesity,
fatty liver disease, and type 2 diabetes. However, the role of intestinal FXR in atherosclerosis …

Mouse models of atherosclerosis in translational research

I Ilyas, PJ Little, Z Liu, Y Xu, D Kamato, BC Berk… - Trends in …, 2022 - cell.com
Atherosclerotic cardiovascular disease (CVD), the major cause of premature human
mortality, is a chronic and progressive metabolic and inflammatory disease in large-and …

Animal models of atherosclerosis–supportive notes and tricks of the trade

A Gisterå, DFJ Ketelhuth, SG Malin… - Circulation …, 2022 - Am Heart Assoc
Atherosclerotic cardiovascular disease is a major cause of death among humans. Animal
models have shown that cholesterol and inflammation are causatively involved in the …

[HTML][HTML] Increased soluble urokinase plasminogen activator levels modulate monocyte function to promote atherosclerosis

G Hindy, DJ Tyrrell, A Vasbinder, C Wei… - The Journal of …, 2022 - Am Soc Clin Investig
People with kidney disease are disproportionately affected by atherosclerosis for unclear
reasons. Soluble urokinase plasminogen activator receptor (suPAR) is an immune-derived …