Hypertension is a leading risk factor for disease burden worldwide. The kidneys, which have
a high specific metabolic rate, play an essential role in the long-term regulation of arterial …

Significance: Renal oxidative stress can be a cause, a consequence, or more often a
potentiating factor for hypertension. Increased reactive oxygen species (ROS) in the kidney …

The unique role of nitric oxide (NO) in the regulation of renal medullary function is supported
by the evidence summarized in this review. The impact of reduced production of NO within …

sible for the remaining reduction of NaCl reabsorption are less clearly understood but
micropuncture studies have demonstrated that this occurs in the loops of Henle of deep …

A classic nephrology reference for over 20 years, Seldin & Giebisch's The Kidney, is the
acknowledged authority on renal physiology and pathophysiology. The fourth edition follows …

The physiological evidence linking the production of superoxide, hydrogen peroxide, and
nitric oxide in the renal medullary thick ascending limb of Henle (mTAL) to regulation of …

The mechanisms of the pathogenesis of preeclampsia, a leading cause of maternal
morbidity and death worldwide, are poorly understood in part due to a lack of spontaneous …

Although initially adaptive, the changes that accompany hypertension, namely, cell growth,
endothelial dysfunction, and extracellular matrix deposition, eventually can become …

The functional balance between angiotensin II (Ang II) and nitric oxide (NO) plays a key role
in modulating salt sensitivity. Estrogen has been shown to downregulate angiotensin type 1 …

Statins, inhibitors of cholesterol biosynthesis, are endowed with pleiotropic effects that may
contribute to their favorable clinical results. Hypertensive Dahl salt-sensitive (DS) rats have …