Osteoarthritis (OA) is the most common form of arthritis and a major cause of pain and
disability in older adults (1). Often OA is referred to as degenerative joint disease “(DJD)” …

Cellular senescence is a state of stable proliferation arrest of cells. The senescence pathway
has many beneficial effects and is seen to be activated in damaged/stressed cells, as well as …

Chondrogenesis occurs as a result of mesenchymal cell condensation and
chondroprogenitor cell differentiation. Following chondrogenesis, the chondrocytes remain …

Human cartilage is a complex tissue of matrix proteins that vary in amount and orientation
from superficial to deep layers and from loaded to unloaded zones. A major challenge to …

Background Articular cartilage defects are a veritable therapeutic problem because
therapeutic options are very scarce. Due to the poor self-regeneration capacity of cartilage …

Aging is the predominant risk factor for neurodegenerative diseases. One key phenotype as
the brain ages is an aberrant innate immune response characterized by proinflammation …

Osteoarthritis (OA) is the most common degenerative joint disease that causes painful
swelling and permanent damage to the joints in the body. The molecular mechanisms of OA …

Osteoarthritis represents the most frequently diagnosed condition of the musculoskeletal
system and accounts for a high amount of direct and indirect socioeconomic costs …

Objective The aim of this study was to characterize the genome‐wide DNA methylation
profile of chondrocytes from knee and hip cartilage obtained from patients with osteoarthritis …

Aging is a natural process characterized by the declining ability of the different organs and
tissues to respond to stress, increasing homeostatic imbalance and risk of disease …