The super family of glutathione S-transferases (GSTs) is composed of multiple isozymes with
significant evidence of functional polymorphic variation. Over the last three decades, data …

Chemoresistance is a multifactorial phenomenon and many studies clearly show that a
coordinated expression of efflux transporter proteins and phase II conjugating enzymes in …

Background: Members of the glutathione S-transferase (GST) superfamily are important in
cellular defense mechanisms. These enzymes attach reduced glutathione to electrophilic …

The major known risk factors for female breast cancer are associated with prolonged
exposure to increased levels of oestrogen. The predominant theory relates to effects of …

Tamoxifen has been a mainstay of adjuvant therapy for breast cancer for many years. We
sought to determine if genetic variability in the tamoxifen metabolic pathway influenced …

The glutathione S-transferases (GSTs) catalyze the GSH-dependent detoxification of
reactive electrophiles such as genotoxic chemical carcinogens and cytotoxic …

Drug-metabolizing enzymes (DME) in tumors are capable of biotransforming a variety of
xenobiotics, including antineoplastics, resulting in either their activation or detoxification …

Resistance to chemotherapy is a major complication in the treatment of advanced breast
cancer. Estrogens and prolactin (PRL) are implicated in the pathogenesis of breast cancer …

Background Breast cancer predisposition genes identified to date (eg, BRCA1 and BRCA2)
are responsible for less than 5% of all breast cancer cases. Many studies have shown that …

Inherent and acquired drug resistance is a cause of chemotherapy failure, and
pharmacogenomic studies have begun to define gene variations responsible for varied drug …