The role of cytokines in nephrotic syndrome

E Ahmadian, Y Rahbar Saadat… - Mediators of …, 2022 - Wiley Online Library
Idiopathic nephrotic syndrome (INS) is an important primary glomerular disease
characterized by severe proteinuria. Evidence supports a role for T cell dysfunction in the …

Role of arachidonic acid and its metabolites in the biological and clinical manifestations of idiopathic nephrotic syndrome

S Turolo, A Edefonti, A Mazzocchi, ML Syren… - International Journal of …, 2021 - mdpi.com
Studies concerning the role of arachidonic acid (AA) and its metabolites in kidney disease
are scarce, and this applies in particular to idiopathic nephrotic syndrome (INS). INS is one …

CD8 T Cell‐Derived Exosomal miR‐186‐5p Elicits Renal Inflammation via Activating Tubular TLR7/8 Signal Axis

X Xu, S Qu, C Zhang, M Zhang, W Qin, G Ren… - Advanced …, 2023 - Wiley Online Library
T cells play an important role in the development of focal segmental glomerulosclerosis
(FSGS). The mechanism underlying such T cell‐based kidney disease, however, remains …

B cell phenotype, activity, and function in idiopathic nephrotic syndrome

J Liu, F Guan - Pediatric Research, 2023 - nature.com
Idiopathic nephrotic syndrome (INS) is the most frequent glomerular disease in childhood.
However, its underlying etiology mechanism lacks thorough understanding. Previous …

Beneficial effects of procyanidin B2 on adriamycin-induced nephrotic syndrome mice: the multi-action mechanism for ameliorating glomerular permselectivity injury

C Zhao, J Tang, X Li, Z Yan, L Zhao, W Lang… - Food & Function, 2022 - pubs.rsc.org
Despite considerable advances in prevention, diagnosis, and therapy, nephrotic syndrome
(NS) remains a significant cause of high morbidity and mortality globally. As a result, there is …

Pediatric patients with steroid-sensitive nephrotic syndrome have higher expression of T regulatory lymphocytes in comparison to steroid-resistant disease

FTL Guimarães, RN Ferreira, GEA Brito-Melo… - Frontiers in …, 2019 - frontiersin.org
Background and Aim: Idiopathic nephrotic syndrome (INS) is classified according to the
response to drug therapy in steroid-sensitive (SS), steroid-dependent (SD), and steroid …

[HTML][HTML] Plasma cytokine profiling to predict steroid resistance in pediatric nephrotic syndrome

S Agrawal, ME Brier, BA Kerlin, WE Smoyer… - Kidney International …, 2021 - Elsevier
Introduction Glucocorticoids (GCs) are the primary treatment for nephrotic syndrome (NS),
although∼ 10% to 20% of children develop steroid-resistant NS (SRNS). Unfortunately …

Evidence for a role of angiotensin converting enzyme 2 in proteinuria of idiopathic nephrotic syndrome

RS Filha, SVB Pinheiro, T Macedo e Cordeiro… - Bioscience …, 2019 - portlandpress.com
Introduction: Renin angiotensin system (RAS) plays a role in idiopathic nephrotic syndrome
(INS). Most studies investigated only the classical RAS axis. Therefore, the aims of the …

Peripheral blood lymphocyte subsets in children with nephrotic syndrome: a retrospective analysis

Y Deng, Y Ou, CJ Mo, L Huang, X Qin, S Li - BMC nephrology, 2023 - Springer
Background Nephrotic syndrome (NS) in children is widely believed to be associated with
severe changes in the immune system. Based on lymphocyte subset analysis, we examined …

Idiopathic nephrotic syndrome in pediatrics: an up-to-date

R da Silva Filha, K Burini, LG Pires… - Current Pediatric …, 2022 - ingentaconnect.com
Background: Idiopathic or Primary Nephrotic Syndrome (INS) is a common glomerular
disease in pediatric population, characterized by proteinuria, edema and hypoalbuminemia …