Chronic hypoxic exposure induces changes in the structure of pulmonary arteries, as well as
in the biochemical and functional phenotypes of each of the vascular cell types, from the …

Idiopathic pulmonary fibrosis (IPF) is a disabling disease of the lung parenchyma,
characterized by progressive accumulation of scar tissue and myofibroblast activation after …

Pulmonary hypertension (PH) is a common complication of chronic hypoxic lung diseases,
which increase morbidity and mortality. Hypoxic PH has previously been attributed to …

Chronic or sustained pulmonary hypertension is a complication of residence at high
altitudes and chronic lung diseases such as chronic obstructive pulmonary disease, cystic …

Rationale: Pulmonary arterial hypertension (PAH) is a medically incurable disease resulting
in death from right ventricular (RV) failure. Both pulmonary vascular and RV remodeling are …

Mutations in bone morphogenetic protein receptor II (BMPR-II) underlie most heritable cases
of pulmonary arterial hypertension (PAH). However, less than half the individuals who …

Systemic sclerosis (SSc) is a connective tissue disease of autoimmune origin characterized
by vascular dysfunction and extensive fibrosis of the skin and visceral organs. Vascular …

Pulmonary hypertension (PH) is a progressive complex fatal disease of multiple etiologies.
Hyperproliferation and resistance to apoptosis of vascular cells of intimal, medial, and …

Background Bone marrow-derived cells (BMDCs) can either limit or contribute to the process
of pulmonary vascular remodeling. Whether the difference in their effects depends on the …

In pulmonary hypertension the loss of precapillary arterioles results from vascular injury
causing endothelial dysfunction. Endothelial cell migration and proliferation are critical for …