Trends in the development of miRNA bioinformatics tools

L Chen, L Heikkinen, C Wang, Y Yang… - Briefings in …, 2019 - academic.oup.com
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression via
recognition of cognate sequences and interference of transcriptional, translational or …

A network-biology perspective of microRNA function and dysfunction in cancer

CP Bracken, HS Scott, GJ Goodall - Nature Reviews Genetics, 2016 - nature.com
MicroRNAs (miRNAs) participate in most aspects of cellular differentiation and homeostasis,
and consequently have roles in many pathologies, including cancer. These small non …

mirDIP 4.1—integrative database of human microRNA target predictions

T Tokar, C Pastrello, AEM Rossos… - Nucleic acids …, 2018 - academic.oup.com
MicroRNAs are important regulators of gene expression, achieved by binding to the gene to
be regulated. Even with modern high-throughput technologies, it is laborious and expensive …

miRNet-dissecting miRNA-target interactions and functional associations through network-based visual analysis

Y Fan, K Siklenka, SK Arora, P Ribeiro… - Nucleic acids …, 2016 - academic.oup.com
MicroRNAs (miRNAs) can regulate nearly all biological processes and their dysregulation is
implicated in various complex diseases and pathological conditions. Recent years have …

The multiMiR R package and database: integration of microRNA–target interactions along with their disease and drug associations

Y Ru, KJ Kechris, B Tabakoff, P Hoffman… - Nucleic acids …, 2014 - academic.oup.com
Abstract microRNAs (miRNAs) regulate expression by promoting degradation or repressing
translation of target transcripts. miRNA target sites have been catalogued in databases …

Mesenchymal stromal cell-derived extracellular vesicles attenuate dendritic cell maturation and function

M Reis, E Mavin, L Nicholson, K Green… - Frontiers in …, 2018 - frontiersin.org
Mesenchymal stromal cells (MSCs) are potent regulators of immune responses largely
through paracrine signaling. MSC secreted extracellular vesicles (MSC-EVs) are …

miRPathDB 2.0: a novel release of the miRNA Pathway Dictionary Database

T Kehl, F Kern, C Backes, T Fehlmann… - Nucleic acids …, 2020 - academic.oup.com
Since the initial release of miRPathDB, tremendous progress has been made in the field of
microRNA (miRNA) research. New miRNA reference databases have emerged, a vast …

MirGeneDB 2.0: the metazoan microRNA complement

B Fromm, D Domanska, E Høye… - Nucleic Acids …, 2020 - academic.oup.com
Small non-coding RNAs have gained substantial attention due to their roles in animal
development and human disorders. Among them, microRNAs are special because …

Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS

A Varcianna, MA Myszczynska, LM Castelli, B O'Neill… - …, 2019 - thelancet.com
Background Astrocytes regulate neuronal function, synaptic formation and maintenance
partly through secreted extracellular vesicles (EVs). In amyotrophic lateral sclerosis (ALS) …

Extracellular vesicles secreted by atherogenic macrophages transfer microRNA to inhibit cell migration

MA Nguyen, D Karunakaran, M Geoffrion… - … , and vascular biology, 2018 - Am Heart Assoc
Objective—During inflammation, macrophages secrete vesicles carrying RNA, protein, and
lipids as a form of extracellular communication. In the vessel wall, extracellular vesicles …