An overview of the biologic effects of omega-6 oxylipins in humans

GC Shearer, RE Walker - Prostaglandins, Leukotrienes and Essential Fatty …, 2018 - Elsevier
Oxylipins are lipid mediators produced from polyunsaturated fatty acid (PUFA) metabolism,
and are thought to be a molecular explanation for the diverse biological effects of PUFAs …

[HTML][HTML] Nonalcoholic fatty liver disease and omega-3 fatty acids: mechanisms and clinical use

MH Spooner, DB Jump - Annual Review of Nutrition, 2023 - annualreviews.org
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic fatty liver disease
worldwide, particularly in obese and type 2 diabetic individuals. Currently, there are no …

Multiple omics study identifies an interspecies conserved driver for nonalcoholic steatohepatitis

XJ Zhang, ZG She, J Wang, D Sun, LJ Shen… - Science translational …, 2021 - science.org
Lipotoxicity is a recognized pathological trigger and accelerator of nonalcoholic
steatohepatitis (NASH). However, the molecular basis of lipotoxicity-induced NASH remains …

[HTML][HTML] Da-chai-hu decoction ameliorates high fat diet-induced nonalcoholic fatty liver disease through remodeling the gut microbiota and modulating the serum …

H Cui, Y Li, Y Wang, L Jin, L Yang, L Wang… - Frontiers in …, 2020 - frontiersin.org
The dysbiosis in gut microbiota could affect host metabolism and contribute to the
development of nonalcoholic fatty liver disease (NAFLD). Da-Chai-Hu decoction (DCH) has …

Oxidant-specific biomarkers of oxidative stress. Association with atherosclerosis and implication for antioxidant effects

E Niki - Free Radical Biology and Medicine, 2018 - Elsevier
The unregulated oxidative modification of lipids, proteins, and nucleic acids induced by
multiple oxidants has been implicated in the pathogenesis of many diseases. Antioxidants …

[HTML][HTML] Ability of high fat diet to induce liver pathology correlates with the level of linoleic acid and Vitamin E in the diet

DS Graham, G Liu, A Arasteh, XM Yin, S Yan - PLoS One, 2023 - journals.plos.org
Increased uptake of fat, such as through the ingestion of high fat diet (HFD), can lead to fatty
liver diseases and metabolic syndrome. It is not clear whether certain fatty acids may be …

[HTML][HTML] Lipidomic and transcriptomic analysis of western diet-induced nonalcoholic steatohepatitis (NASH) in female Ldlr -/- mice

M Garcia-Jaramillo, MH Spooner, CV Löhr, CP Wong… - PloS one, 2019 - journals.plos.org
Background Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver
disease worldwide, particularly in obese and type 2 diabetic individuals. NAFLD ranges in …

Diesel exhaust induces mitochondrial dysfunction, hyperlipidemia, and liver steatosis

F Yin, R Gupta, L Vergnes, WS Driscoll… - … , and vascular biology, 2019 - Am Heart Assoc
Objective: Air pollution is associated with increased cardiovascular morbidity and mortality,
as well as dyslipidemia and metabolic syndrome. Our goal was to dissect the mechanisms …

Effect of inflammation on cytochrome P450-mediated arachidonic acid metabolism and the consequences on cardiac hypertrophy

MAW ElKhatib, FA Isse, AOS El-Kadi - Drug Metabolism Reviews, 2023 - Taylor & Francis
The incidence of heart failure (HF) is generally preceded by cardiac hypertrophy (CH), which
is the enlargement of cardiac myocytes in response to stress. During CH, the metabolism of …

[HTML][HTML] Gigantol ameliorates CCl4-induced liver injury via preventing activation of JNK/cPLA2/12-LOX inflammatory pathway

Y Xue, Q Deng, Q Zhang, Z Ma, B Chen, X Yu… - Scientific Reports, 2020 - nature.com
Arachidonic acid (AA) signaling pathway is an important constituent of inflammatory
processes. In our previous study, it was found that dihydro-stilbene gigantol relieved hepatic …