The role of biomolecular condensates in protein aggregation
There is an increasing amount of evidence that biomolecular condensates are linked to
neurodegenerative diseases associated with protein aggregation, such as Alzheimer's …
neurodegenerative diseases associated with protein aggregation, such as Alzheimer's …
Theory and simulation of multiphase coexistence in biomolecular mixtures
WM Jacobs - Journal of Chemical Theory and Computation, 2023 - ACS Publications
Biomolecular condensates constitute a newly recognized form of spatial organization in
living cells. Although many condensates are believed to form as a result of phase …
living cells. Although many condensates are believed to form as a result of phase …
The liquid-to-solid transition of FUS is promoted by the condensate surface
A wide range of macromolecules can undergo phase separation, forming biomolecular
condensates in living cells. These membraneless organelles are typically highly dynamic …
condensates in living cells. These membraneless organelles are typically highly dynamic …
Single-molecule FRET unmasks structural subpopulations and crucial molecular events during FUS low-complexity domain phase separation
Biomolecular condensates formed via phase separation of proteins and nucleic acids are
thought to be associated with a wide range of cellular functions and dysfunctions. We dissect …
thought to be associated with a wide range of cellular functions and dysfunctions. We dissect …
The interface of condensates of the hnRNPA1 low-complexity domain promotes formation of amyloid fibrils
M Linsenmeier, L Faltova, C Morelli… - Nature …, 2023 - nature.com
The maturation of liquid-like protein condensates into amyloid fibrils has been associated
with several neurodegenerative diseases. However, the molecular mechanisms underlying …
with several neurodegenerative diseases. However, the molecular mechanisms underlying …
A solid beta-sheet structure is formed at the surface of FUS droplets during aging
Phase transitions are important to understand cell dynamics, and the maturation of liquid
droplets is relevant to neurodegenerative disorders. We combined NMR and Raman …
droplets is relevant to neurodegenerative disorders. We combined NMR and Raman …
Dynamical control enables the formation of demixed biomolecular condensates
Cellular matter can be organized into compositionally distinct biomolecular condensates.
For example, in Ashbya gossypii, the RNA-binding protein Whi3 forms distinct condensates …
For example, in Ashbya gossypii, the RNA-binding protein Whi3 forms distinct condensates …
Multivalent interactions between molecular components involved in fast endophilin mediated endocytosis drive protein phase separation
A specific group of transmembrane receptors, including the β1-adrenergic receptor (β1-AR),
is internalized through a non-clathrin pathway known as Fast Endophilin Mediated …
is internalized through a non-clathrin pathway known as Fast Endophilin Mediated …
Fundamental Aspects of Phase-Separated Biomolecular Condensates
Biomolecular condensates, formed through phase separation, are upending our
understanding in much of molecular, cell, and developmental biology. There is an urgent …
understanding in much of molecular, cell, and developmental biology. There is an urgent …
Protein structural transitions critically transform the network connectivity and viscoelasticity of RNA-binding protein condensates but RNA can prevent it
AR Tejedor, I Sanchez-Burgos… - Nature …, 2022 - nature.com
Biomolecular condensates, some of which are liquid-like during health, can age over time
becoming gel-like pathological systems. One potential source of loss of liquid-like properties …
becoming gel-like pathological systems. One potential source of loss of liquid-like properties …