Actomyosin forces in cell migration: Moving beyond cell body retraction

K Weißenbruch, R Mayor - Bioessays, 2024 - Wiley Online Library
In textbook illustrations of migrating cells, actomyosin contractility is typically depicted as the
contraction force necessary for cell body retraction. This dogma has been transformed by the …

[HTML][HTML] Exploring the nexus between MYH9 and tumors: novel insights and new therapeutic opportunities

Z Gou, D Zhang, H Cao, Y Li, Y Li, Z Zhao… - Frontiers in Cell and …, 2024 - frontiersin.org
The myosin heavy chain 9 (MYH9) gene, located on human chromosome 22, encodes non-
muscle myosin heavy chain IIA (NM IIA). This protein is essential to various cellular events …

Limiting pool and actin architecture controls myosin cluster sizes in adherent cells

WH Chou, M Molaei, H Wu, PW Oakes, JR Beach… - Biophysical …, 2024 - cell.com
The actomyosin cytoskeleton generates mechanical forces that power important cellular
processes, such as cell migration, cell division, and mechanosensing. Actomyosin self …

Myosin superfamily members during myelin formation and regeneration

R Yamazaki, N Ohno - Journal of Neurochemistry, 2024 - Wiley Online Library
Myelin is an insulator that forms around axons that enhance the conduction velocity of nerve
fibers. Oligodendrocytes dramatically change cell morphology to produce myelin throughout …

[HTML][HTML] Structure, regulation, and mechanisms of nonmuscle myosin-2

K Chinthalapudi, SM Heissler - Cellular and Molecular Life Sciences, 2024 - Springer
Members of the myosin superfamily of molecular motors are large mechanochemical
ATPases that are implicated in an ever-expanding array of cellular functions. This review …

First-passage times in complex energy landscapes: a case study with nonmuscle myosin II assembly

R Bebon, US Schwarz - New Journal of Physics, 2022 - iopscience.iop.org
Complex energy landscapes often arise in biological systems, eg for protein folding,
biochemical reactions, or intracellular transport processes. Their physical effects are …

Segregation, Finite Time Elastic Singularities and Coarsening in Renewable Active Matter

A Roychowdhury, S Dasgupta, M Rao - bioRxiv, 2024 - biorxiv.org
Material renewability in active living systems, such as in cells and tissues, can drive the
large-scale patterning of forces, with distinctive phenotypic consequences. This is especially …

Cell mechanics and mechanobiology

US Schwarz, M Vicente-Manzanares - 2023 - digital.csic.es
The field of cell mechanics and mechanobiology has seen immense growth over the last
three decades and still is growing at an amazing pace. An overarching definition of …