Towards smart biomanufacturing: a perspective on recent developments in industrial measurement and monitoring technologies for bio-based production processes
CL Gargalo, I Udugama, K Pontius… - Journal of Industrial …, 2020 - academic.oup.com
The biomanufacturing industry has now the opportunity to upgrade its production processes
to be in harmony with the latest industrial revolution. Technology creates capabilities that …
to be in harmony with the latest industrial revolution. Technology creates capabilities that …
Sensor systems for bioprocess monitoring
P Biechele, C Busse, D Solle… - Engineering in Life …, 2015 - Wiley Online Library
The ability to measure all process variables is of great importance in the field of bioprocess
monitoring and control, and continuous, real‐time measurements are highly desired. The …
monitoring and control, and continuous, real‐time measurements are highly desired. The …
Real time monitoring of multiple parameters in mammalian cell culture bioreactors using an in‐line Raman spectroscopy probe
NR Abu‐Absi, BM Kenty, ME Cuellar… - Biotechnology and …, 2011 - Wiley Online Library
The FDA's process analytical technology initiative encourages drug manufacturers to apply
innovative ideas to better understand their processes. There are many challenges to …
innovative ideas to better understand their processes. There are many challenges to …
Spectroscopic sensors for in-line bioprocess monitoring in research and pharmaceutical industrial application
J Claßen, F Aupert, KF Reardon, D Solle… - Analytical and …, 2017 - Springer
The use of spectroscopic sensors for bioprocess monitoring is a powerful tool within the
process analytical technology (PAT) initiative of the US Food and Drug Administration …
process analytical technology (PAT) initiative of the US Food and Drug Administration …
Electrochemical biosensors for food bioprocess monitoring
During the last years, the use of biosensors in food analysis has gained considerable
interest. These analytical devices provide highly selective, sensitive and cost-effective …
interest. These analytical devices provide highly selective, sensitive and cost-effective …
The systematic production of cells for cell therapies
DC Kirouac, PW Zandstra - Cell stem cell, 2008 - cell.com
Stem cells have emerged as the starting material of choice for bioprocesses to produce cells
and tissues to treat degenerative, genetic, and immunological disease. Translating the …
and tissues to treat degenerative, genetic, and immunological disease. Translating the …
Between the poles of data‐driven and mechanistic modeling for process operation
D Solle, B Hitzmann, C Herwig… - Chemie Ingenieur …, 2017 - Wiley Online Library
The best method for process control is the use of model‐based solutions, based on process
analytical technology for online monitoring of critical process variables, product quality …
analytical technology for online monitoring of critical process variables, product quality …
Quick generation of R aman spectroscopy based in‐process glucose control to influence biopharmaceutical protein product quality during mammalian cell culture
BN Berry, TM Dobrowsky, RC Timson… - Biotechnology …, 2016 - Wiley Online Library
Mitigating risks to biotherapeutic protein production processes and products has driven the
development of targeted process analytical technology (PAT); however implementing PAT …
development of targeted process analytical technology (PAT); however implementing PAT …
In situ Raman spectroscopy for simultaneous monitoring of multiple process parameters in mammalian cell culture bioreactors
J Whelan, S Craven, B Glennon - Biotechnology progress, 2012 - Wiley Online Library
In this study, the application of Raman spectroscopy to the simultaneous quantitative
determination of glucose, glutamine, lactate, ammonia, glutamate, total cell density (TCD) …
determination of glucose, glutamine, lactate, ammonia, glutamate, total cell density (TCD) …
Advances in sensor developments for cell culture monitoring
Cell culture encompasses procedures for extracting cells from their natural tissue and
cultivating them under controlled artificial conditions. During this process, various factors …
cultivating them under controlled artificial conditions. During this process, various factors …