Generation of gut‐homing T cells and their localization to the small intestinal mucosa

B Johansson‐Lindbom, WW Agace - Immunological reviews, 2007 - Wiley Online Library
The intestinal mucosa represents the largest body surface toward the external environment
and harbors numerous T lymphocytes that take up resident within the intestinal epithelium or …

Immunopathogenesis of inflammatory bowel diseases

MF Neurath, G Schürmann - Der chirurg, 2000 - Springer
Die chronisch entzündlichen Darmerkrankungen (CED: Morbus Crohn, Colitis ulcerosa)
sind durch schubartig verlaufende destruierende Entzündungsreaktionen der …

Parenteral nutrition impairs lymphotoxin β receptor signaling via NF-κB

J Lan, AF Heneghan, Y Sano, MA Jonker… - Annals of …, 2011 - journals.lww.com
Objective: To determine effects of (1) parenteral nutrition (PN),(2) exogenous Lymphotoxin β
receptor (LTβR) stimulation in PN animals, and (3) exogenous LTβR blockade in chow …

Granulomatous inflammation during Heligmosomoides polygyrus primary infections in FVB mice

A Cywińska, K Czumińska… - Journal of …, 2004 - cambridge.org
Host responses to primary infections with Heligmosomoides polygyrus were studied in fast
responding FVB mice (H-2q). Pathological changes in the intestinal mucosa, mesenteric …

l-selectin and α4β7 integrin, but not ICAM-1, regulate lymphocyte distribution in gut-associated lymphoid tissue of mice

SR Reese, KA Kudsk, L Genton, S Ikeda - Surgery, 2005 - Elsevier
BACKGROUND: Adhesion molecules on lymphocytes (l-selectin and α4β7) and
endothelium (MAdCAM-1 and ICAM-1) direct lymphocytes into the gut-associated lymphoid …

Immunotherapeutic approaches to inflammatory bowel diseases

MH Holtmann, PR Galle, MF Neurath - Expert Opinion on Biological …, 2001 - Taylor & Francis
For a long time corticosteroids, aminosalicylic acid preparations and antibiotics have
represented the principal approaches in evidence-based drug therapy for chronic …

Zur Immunpathogenese der chronisch entzndlichen Darmerkrankungen

MF Neurath, G Schrmann - Der Chirurg, 2000 - infona.pl
Die chronisch entzndlichen Darmerkrankungen (CED: Morbus Crohn, Colitis ulcerosa) sind
durch schubartig verlaufende destruierende Entzndungsreaktionen der Darmschleimhaut …

Analysis of adhesion molecules involved in leukocyte homing into the basolateral pockets of mouse Peyer's patch M cells

NJ Mantis, J Wagner - Journal of drug targeting, 2004 - Taylor & Francis
The basolateral membranes of intestinal M cells are invaginated to form large intraepithelial
“pockets” that are populated by specific sub-sets of mucosal leukocytes, including CD4+ T …

β1 integrins are not required for the maintenance of lymphocytes within intestinal epithelia

J Marsal, C Brakebusch, G Bungartz… - European journal of …, 2005 - Wiley Online Library
Abstract β1 integrins are thought to play a central role in maintaining lymphocytes within
mucosal epithelia via their interactions with extracellular matrix proteins and subepithelial …

Development of T cell lineages in rat lacrimal glands

NL O'Sullivan, CA Skandera… - Current Eye …, 2001 - Taylor & Francis
Purpose. The purpose of this study was to examine T cell development in rat lacrimal
glands, determine whether the thymus is the source of immature T cells in this tissue and …