Omics approaches are high-throughput unbiased technologies that provide snapshots of
various aspects of biological systems and include: 1) genomics, the measure of DNA …

Human peripheral blood mononuclear cells (PBMCs) are the key drivers of the immune
responses. These cells undergo activation, proliferation and differentiation into various …

Abstract microRNAs (miRNAs) regulate expression by promoting degradation or repressing
translation of target transcripts. miRNA target sites have been catalogued in databases …

Rationale: Chronic obstructive pulmonary disease (COPD) occurs in a minority of smokers
and is characterized by intermittent exacerbations and clinical subphenotypes such as …

Water-soluble inorganic (WSI) ions are major components of ambient air PM2. 5 (particulate
matter of diameter≤ 2.5 μm); however, their potential health effects are understudied. On …

Sphingolipid bioactivities in the respiratory airways and the roles of the proteins that handle
them have been extensively investigated. Gas or inhaled particles or microorganisms come …

Bronchiectasis is a complex and heterogeneous inflammatory chronic respiratory disease
with an unknown cause in around 30–40% of patients. The presence of airway infection …

Implementing precision medicine for complex diseases such as chronic obstructive lung
disease (COPD) will require extensive use of biomarkers and an in-depth understanding of …

Chronic obstructive pulmonary disease (COPD) comprises multiple phenotypes such as
airflow obstruction, emphysema, and frequent episodes of acute worsening of respiratory …

Systemic inflammation is established as part of late-stage severe lung disease, but
molecular, functional, and phenotypic changes in peripheral immune cells in early disease …