The endothelium can evoke relaxations of the underlying vascular smooth muscle, by
releasing vasodilator substances. The best‐characterized endothelium‐derived relaxing …

Twenty years ago, Rho-kinase was identified as an important downstream effector of the
small GTP-binding protein, RhoA. Thereafter, a series of studies demonstrated the important …

Abstract Aims Sodium-glucose-cotransporter-2 inhibitors showed favourable cardiovascular
outcomes, but the underlying mechanisms are still elusive. This study investigated the …

Background Inflammation, oxidative stress, and apoptosis contribute to the evolution of
doxorubicin (DOX)‐induced cardiotoxicity. Osteocrin (OSTN) is a novel secretory peptide …

Oxidative stress has long been implicated in cardiovascular disease, but more recently, the
role of reactive oxygen species (ROS) in normal physiological signaling has been …

The complex physiological signal transduction networks that respond to the dual challenges
of inflammatory and oxidative stress are major factors that promote the development of …

Accumulating evidence has demonstrated the importance of reactive oxygen species (ROS)
as an essential second messenger in health and disease. Endothelial dysfunction is the …

The endothelium plays a pivotal role in the regulation of vascular tone by synthesizing and
liberating endothelium-derived relaxing factors inclusive of vasodilator prostaglandins (eg …

The endothelium plays crucial roles in modulating vascular tone by synthesizing and
releasing endothelium‐derived relaxing factors (EDRFs), including vasodilator …

Diffuse and focal epicardial coronary disease and coronary microvascular abnormalities
may exist side-by-side. Identifying the contributions of each of these three players in the …