Cancer stem cells (CSCs) show a self-renewal capacity and differentiation potential that
contribute to tumor progression and therapy resistance. However, the underlying processes …

The tumor microenvironment has been recently reported to play a pivotal role in sustaining
tumor cells survival and protecting them from immunotherapy and chemotherapy-induced …

Regulatory networks that maintain functional, differentiated cell states are often dysregulated
in tumor development. Here, we use single-cell epigenomics to profile chromatin state …

Yes‑associated protein (YAP) acts as a transcriptional co‑activator in gene expression and
cell proliferation control by binding to the transcriptional factor TEA domain (TEAD) of the …

Head and neck squamous cell carcinoma (HNSCC) is the most common type of head and
neck tumor. It is a high incidence malignant tumor associated with a low survival rate and …

Acetyl-coenzyme A (acetyl-CoA), an essential metabolite, not only takes part in numerous
intracellular metabolic processes, powers the tricarboxylic acid cycle, serves as a key hub …

The Wnt/β-catenin signaling pathway is associated with the regulation of cancer stem cells,
and it can be driven by epigenetic modifications. Here, we aim to identify epigenetic …

Background Oral squamous cell carcinoma (OSCC) is a malignant oral cavity neoplasm that
affects many people, especially in developing countries. Despite several advances that have …

Objective Oral cancer is the sixteenth most prevalent cancer in the world and the third-most
in India. Despite of several treatment modalities, the cure rate of oral cancer is still low due to …

Oral cancer is a public health problem with an incidence of almost 50,000 and a mortality of
10,000 each year in the USA alone. Black raspberries (BRBs) have been shown to inhibit …