Red risks for a journey to the red planet: The highest priority human health risks for a mission to Mars

ZS Patel, TJ Brunstetter, WJ Tarver, AM Whitmire… - npj …, 2020 - nature.com
NASA's plans for space exploration include a return to the Moon to stay—boots back on the
lunar surface with an orbital outpost. This station will be a launch point for voyages to …

[HTML][HTML] Carcinogenesis induced by space radiation: A systematic review

Z Guo, G Zhou, W Hu - Neoplasia, 2022 - Elsevier
The carcinogenic risk from space radiation has always been a health risk issue of great
concern during space exploration. In recent years, a large number of cellular and animal …

Low-energy electron damage to condensed-phase DNA and its constituents

Y Gao, Y Zheng, L Sanche - International Journal of Molecular Sciences, 2021 - mdpi.com
The complex physical and chemical reactions between the large number of low-energy (0–
30 eV) electrons (LEEs) released by high energy radiation interacting with genetic material …

Understanding the complexities and changes of the astronaut microbiome for successful long-duration space missions

D Tesei, A Jewczynko, AM Lynch, C Urbaniak - Life, 2022 - mdpi.com
During space missions, astronauts are faced with a variety of challenges that are unique to
spaceflight and that have been known to cause physiological changes in humans over a …

The kidney, volume homeostasis and osmoregulation in space: current perspective and knowledge gaps

RHG Olde Engberink, PJ van Oosten, T Weber… - npj …, 2023 - nature.com
Although we have sent humans into space for more than 50 years crucial questions
regarding kidney physiology, volume regulation and osmoregulation remain unanswered …

Simulated microgravity‐induced oxidative stress and loss of osteogenic potential of osteoblasts can be prevented by protection of primary cilia

LW Miao, TZ Liu, YH Sun, N Cai… - Journal of Cellular …, 2023 - Wiley Online Library
Oxidative stress has been considered to be closely related to spaceflight‐induced bone loss;
however, mechanism is elusive and there are no effective countermeasures. Using cultured …

[HTML][HTML] Intestinal stem cells acquire premature senescence and senescence associated secretory phenotype concurrent with persistent DNA damage after heavy ion …

S Kumar, S Suman, AJ Fornace Jr, K Datta - Aging (Albany NY), 2019 - ncbi.nlm.nih.gov
Heavy ion radiation, prevalent in outer space and relevant for radiotherapy, is densely
ionizing and poses risk to stem cells that are key to intestinal homeostasis. Currently, the …

Oxidative stress and the kidney in the space environment

P Pavlakou, E Dounousi, S Roumeliotis… - International Journal of …, 2018 - mdpi.com
In space, the special conditions of hypogravity and exposure to cosmic radiation have
substantial differences compared to terrestrial circumstances, and a multidimensional impact …

Evidence report: risk of radiation carcinogenesis

J Huff, L Carnell, S Blattnig, L Chappell, G Kerry… - 2016 - ntrs.nasa.gov
As noted by Durante and Cucinotta (2008), cancer risk caused by exposure to space
radiation is now generally considered a main hindrance to interplanetary travel for the …

Genomic changes driven by radiation-induced DNA damage and microgravity in human cells

A Beheshti, JT McDonald, M Hada… - International Journal of …, 2021 - mdpi.com
The space environment consists of a complex mixture of different types of ionizing radiation
and altered gravity that represents a threat to humans during space missions. In particular …