[HTML][HTML] Age-related macular degeneration: Epidemiology, genetics, pathophysiology, diagnosis, and targeted therapy

Y Deng, L Qiao, M Du, C Qu, L Wan, J Li, L Huang - Genes & diseases, 2022 - Elsevier
Age-related macular degeneration (AMD) is a complex eye disorder and is the leading
cause of incurable blindness worldwide in the elderly. Clinically, AMD initially affects the …

The complement system in age-related macular degeneration

A Armento, M Ueffing, SJ Clark - Cellular and Molecular Life Sciences, 2021 - Springer
Age-related macular degeneration (AMD) is a chronic and progressive degenerative
disease of the retina, which culminates in blindness and affects mainly the elderly …

A resource-efficient tool for mixed model association analysis of large-scale data

L Jiang, Z Zheng, T Qi, KE Kemper, NR Wray… - Nature …, 2019 - nature.com
The genome-wide association study (GWAS) has been widely used as an experimental
design to detect associations between genetic variants and a phenotype. Two major …

Reticular pseudodrusen: a critical phenotype in age-related macular degeneration

Z Wu, EL Fletcher, H Kumar, U Greferath… - Progress in retinal and …, 2022 - Elsevier
Reticular pseudodrusen (RPD), or subretinal drusenoid deposits (SDD), refer to distinct
lesions that occur in the subretinal space. Over the past three decades, their presence in …

IMI–myopia genetics report

MS Tedja, AEG Haarman… - … & visual science, 2019 - iovs.arvojournals.org
IMI – Myopia Genetics Report | IOVS | ARVO Journals iovs Issues Topics For Authors About
Editorial Board Journals Home MANAGE ALERTS Access Provided By: Google Indexer Forgot …

Age-related macular degeneration preferred practice pattern®

CJ Flaxel, RA Adelman, ST Bailey, A Fawzi, JI Lim… - …, 2020 - aaojournal.org
Background: Age-related macular degeneration is a leading cause of severe, irreversible
vision impairment in developed countries. The primary risk factors for the development of …

Five years of GWAS discovery

PM Visscher, MA Brown, MI McCarthy… - The American Journal of …, 2012 - cell.com
The past five years have seen many scientific and biological discoveries made through the
experimental design of genome-wide association studies (GWASs). These studies were …

Risk factors and biomarkers of age-related macular degeneration

NG Lambert, H ElShelmani, MK Singh… - Progress in retinal and …, 2016 - Elsevier
A biomarker can be a substance or structure measured in body parts, fluids or products that
can affect or predict disease incidence. As age-related macular degeneration (AMD) is the …

Understanding age-related macular degeneration (AMD): relationships between the photoreceptor/retinal pigment epithelium/Bruch's membrane/choriocapillaris …

I Bhutto, G Lutty - Molecular aspects of medicine, 2012 - Elsevier
There is a mutualistic symbiotic relationship between the components of the
photoreceptor/retinal pigment epithelium (RPE)/Bruch's membrane (BrMb)/choriocapillaris …

Seven new loci associated with age-related macular degeneration

Nature genetics, 2013 - nature.com
Age-related macular degeneration (AMD) is a common cause of blindness in older
individuals. To accelerate the understanding of AMD biology and help design new …