As angiogenesis is essential for tumor growth and metastasis, controlling tumor-associated
angiogenesis is a promising tactic in limiting cancer progression. The tumor …

Endothelial cell migration is essential to angiogenesis. This motile process is directionally
regulated by chemotactic, haptotactic, and mechanotactic stimuli and further involves …

Cancer-associated fibroblasts (CAFs) are major components of the carcinoma
microenvironment that promote tumor progression. However, the mechanisms by which …

Targeted drug delivery vehicles with low immunogenicity and toxicity are needed for cancer
therapy. Here we show that exosomes, endogenous nano-sized membrane vesicles …

In addition to their adhesive functions, cell-adhesion molecules modulate signal-
transduction pathways by interacting with molecules such as receptor tyrosine kinases …

Fibroblast growth factors (FGFs) are a family of heparin-binding growth factors. FGFs exert
their pro-angiogenic activity by interacting with various endothelial cell surface receptors …

Akt is a serine/threonine protein kinase that is activated by a number of growth factors and
cytokines in a phosphatidylinositol-3 kinase–dependent manner. Although antiapoptotic …

Background: Activin receptor-like kinase 1 (ALK1) is an endothelial transmembrane serine
threonine kinase receptor for BMP family ligands that plays a critical role in cardiovascular …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal human cancers due to its
complicated genomic instability. PDAC frequently presents at an advanced stage with …

Tissue mechanics provide an important context for tissue growth, maintenance and function.
On the level of organs, external mechanical forces largely influence the control of tissue …