At the frontline of the host defence response, neutrophil antimicrobial functions have
adapted to combat infections and injuries of different origins and magnitude. The release of …

Neutrophils are critical to innate immunity, including host defense against bacterial and
fungal infections. They achieve their host defense role by phagocytosing pathogens …

Lung metastasis is the major cause of breast cancer-related mortality. The neutrophil-
associated inflammatory microenvironment aids tumor cells in metastatic colonization in …

This review will briefly outline the major signaling pathways in PMA-activated neutrophils.
PMA is widely used to understand neutrophil pathways and formation of NETs. PMA …

Extracellular chromatin, for example in the form of neutrophil extracellular traps (NETs), is an
important element that propels the pathological progression of a plethora of diseases. DNA …

The cell nucleus is best known as the container of the genome. Its envelope provides a
barrier for passive macromolecule diffusion, which enhances the control of gene expression …

The nuclear lamins are polymeric intermediate filament proteins that scaffold the nucleus
and organize the genome in nearly all eukaryotic cells. This review focuses on the dynamic …

Polymorphonuclear neutrophils (PMNs) are traditionally regarded as professional
phagocytic and acute inflammatory cells that engulf the microbial pathogens. However …

Lamins are the ancient type V intermediate filament proteins contributing to diverse
biological functions, such as the maintenance of nuclear morphology, stabilization of …

All cells must die at some point, and the dogma is that they do it either silently via apoptosis
or via pro-inflammatory, lytic forms of death. Amongst these lytic cell death pathways …