The spectrum of ischaemic cardiomyopathy, encompassing acute myocardial infarction to
congestive heart failure is a significant clinical issue in the modern era. This group of …

Retinopathy of prematurity (ROP) is a disease that can cause blindness in very low
birthweight infants. The incidence of ROP is closely correlated with the weight and the …

It is widely believed that perinatal cardiomyocyte terminal differentiation blocks cytokinesis,
thereby causing binucleation and limiting regenerative repair after injury. This suggests that …

Aging is a biological process that affects most cells, organisms and species. Telomeres have
been postulated as a universal biological clock that shortens in parallel with aging in cells …

Anemia is a common comorbidity in patients with heart failure and is associated with worse
long-term outcomes. Although the cause of anemia in heart failure is unclear, the weight of …

In the haematopoietic system, the principal function of erythropoietin (Epo) is the regulation
of red blood cell production, mediated by its specific cell surface receptor (EpoR). Following …

Anemia and iron deficiency are common in patients with heart failure (HF), and are
associated with worse symptoms and adverse outcomes in this population. Although the two …

Metformin is the first choice drug for the treatment of patients with diabetes, but its use is
debated in patients with advanced cardiorenal disease. Epidemiological data suggest that …

Erythropoietin (EPO) is the main hematopoietic hormone acting on progenitor red blood
cells via stimulation of cell growth, differentiation, and anti-apoptosis. However, its receptor …

Peripheral arterial disease (PAD) is a common vascular disease that reduces blood flow
capacity to the legs of patients. PAD leads to exercise intolerance that can progress in …