[PDF][PDF] Optogenetic user's guide to Opto-GPCRs
S Kleinlogel - Front. Biosci, 2016 - article.imrpress.com
Optogenetics has taken biomedical research by storm. The power and precision at which
light-gated ion channels control cellular excitability in diverse biological systems has …
light-gated ion channels control cellular excitability in diverse biological systems has …
Identification of Novel Dopamine D2 Receptor Ligands—A Combined In Silico/In Vitro Approach
L Zell, C Lainer, J Kollár, V Temml, D Schuster - Molecules, 2022 - mdpi.com
Diseases of the central nervous system are an alarming global problem showing an
increasing prevalence. Dopamine receptor D2 (D2R) has been shown to be involved in …
increasing prevalence. Dopamine receptor D2 (D2R) has been shown to be involved in …
Structural optimizations and bioevaluation of NH aporphine analogues as Gq-biased and selective serotonin 5-HT2C receptor agonists
The concept of subtype selectivity and functional bias has recently reshaped current GPCR
drug discovery for G protein-coupled receptors. A series of new NH aporphines with A-ring …
drug discovery for G protein-coupled receptors. A series of new NH aporphines with A-ring …
Higher-Affinity Agonists of 5-HT1AR Discovered through Tuning the Binding-Site Flexibility
Discovery of high-affinity and high-selectivity agonists of 5-HT1AR has become very
attractive due to their potential therapeutic effects on multiple 5-HT1AR-related …
attractive due to their potential therapeutic effects on multiple 5-HT1AR-related …
Decreased expression of PTH1R is a poor prognosis in hepatocellular carcinoma
HJ Wang, L Wang, SS Song, XL He, HY Pan… - Cancer …, 2018 - content.iospress.com
BACKGROUND AND AIM: Hypercalcemia is a potentially fatal and not rare complication of
hepatocellular carcinoma (HCC), and its underlying mechanism remains unclear …
hepatocellular carcinoma (HCC), and its underlying mechanism remains unclear …
Dopamine Receptor Ligand Selectivity—An In Silico/In Vitro Insight
L Zell, A Bretl, V Temml, D Schuster - Biomedicines, 2023 - mdpi.com
Different dopamine receptor (DR) subtypes are involved in pathophysiological conditions
such as Parkinson's Disease (PD), schizophrenia and depression. While many DR-targeting …
such as Parkinson's Disease (PD), schizophrenia and depression. While many DR-targeting …