High‐pressure (HP) NMR spectroscopy is an important method for detecting rare functional
states of proteins by analyzing the pressure response of chemical shifts. However, for the …

Abstract Characterization of native GTP‐bound Ras is important for an appreciation of its
cellular signaling and for the design of inhibitors, which however has been depressed by its …

The energetic and volumetric properties of a three‐state protein folding system, comprising a
metastable triple mutant of the Fyn SH3 domain, have been investigated using pressure …

The recent discovery of inhibitory compounds binding to distinct pockets on GDP‐bound
Ras has renewed the view on the druggability of this crucial cancer driver. However, the …

As one of the first oncogenes to be discovered and one of the most prevalently mutated
tumor genes, Ras is one of the most (in) famous genes for cancer researchers and clinicians …

A non‐magnetic piston‐cylinder pressure cell is presented for solution‐state NMR
spectroscopy at geochemical pressures. The probe has been calibrated up to 20 kbar using …

Eines der erstentdeckten Onkogene und am meisten von Mutationen betroffenen
Tumorgene ist Ras. Nun gelang die Entdeckung allosterischer Inhibitoren sowie …

Abstract Die Hochdruck‐NMR‐Spektroskopie ist wichtig für die Detektion selten auftretender
Proteinzustände mithilfe der Druckabhängigkeit der chemischen Verschiebung. Für die …