The canonical role of the hemostatic and fibrinolytic systems is to maintain vascular integrity.
Perturbations in either system can prompt primary pathological end points of hemorrhage or …

Acetaminophen (APAP) overdose is the leading cause of drug-induced acute liver failure in
many developed countries. Mitochondrial oxidative stress is considered to be the …

Obesity promotes a chronic inflammatory and hypercoagulable state that drives
cardiovascular disease, type 2 diabetes, fatty liver disease, and several cancers. Elevated …

Acetaminophen/paracetamol (APAP) overdose is the leading cause of drug-induced acute
liver failure (ALF) in the United States and Europe. The progression of the disease is …

Kupffer cells (KCs) are key regulators of liver immunity composing the principal part of
hepatic macrophages even body tissue macrophages. They reside in liver sinusoids …

Acetaminophen (APAP) is the leading cause of drug-induced acute liver failure.
Sphingosine-1-phosphate (S1P), whose formation is catalyzed by sphingosine kinase …

Mesenchymal stem cells (MSCs) transplantation is a promising antifibrotic strategy but
facing clinical controversies. Inspired by advances in nanomedicine, we aimed to bypass …

Acetaminophen (APAP), a widely used antipyretic and analgesic drug in clinics, is relatively
safe at therapeutic doses; however, APAP overdose may lead to fatal acute liver injury …

Acetaminophen (APAP)-induced injury is a common clinical phenomenon that not only
occurs in a dose-dependent manner but also occurs in some idiosyncratic individuals in a …

Healthy Kupffer cell (KC) pool is dominated by embryonic KCs (EmKCs), preserving liver
homeostasis. How the KC pool varies upon injury remains unclear. Using chimeric mice with …