A fundamental challenge for the survival of all organisms is maintaining the integrity of the
genome in all cells. Cells must therefore segregate their replicated genome equally during …

In virtually every eukaryotic species, the ends of nuclear chromosomes are protected by
telomeres, nucleoprotein structures counteracting the end-replication problem and …

Centromere sequences are not conserved between species, and there is compelling
evidence for epigenetic regulation of centromere identity, with location being dictated by the …

A chromosome is composed of structurally and functionally distinct domains. However, the
molecular mechanisms underlying the formation of chromatin structure and the function of …

Telomeric repeats in fungi of the subphylum Saccharomycotina exhibit great inter-and intra-
species variability in length and sequence. Such variations challenged telomeric DNA …

CENP‐A is a centromere‐specific variant of histone H 3 that is required for accurate
chromosome segregation. The fission yeast S chizosaccharomyces pombe and mammalian …

AMS2, am ulticopy s uppressor for the cpn1 (SpCENP-A) mutant, functions to specifically
regulate histone genes transcription and chromosome segregation. As a cell-cycle …

Telomeric sequences constitute only a small fraction of the whole genome yet they are
crucial for ensuring genomic stability. This function is in large part mediated by protein …

HIRA is an evolutionarily conserved histone chaperone that mediates replication-
independent nucleosome assembly and is important for a variety of processes such as cell …

Telomeres of nuclear chromosomes are usually composed of an array of tandemly repeated
sequences that are recognized by specific Myb domain containing DNA-binding proteins …