Developing recombinant antibodies by phage display against infectious diseases and toxins for diagnostics and therapy

KDR Roth, EV Wenzel, M Ruschig, S Steinke… - Frontiers in cellular …, 2021 - frontiersin.org
Antibodies are essential molecules for diagnosis and treatment of diseases caused by
pathogens and their toxins. Antibodies were integrated in our medical repertoire against …

Phage display antibody libraries: A robust approach for generation of recombinant human monoclonal antibodies

R Kumar, HA Parray, T Shrivastava, S Sinha… - International journal of …, 2019 - Elsevier
Monoclonal antibodies (mAbs) and their derivatives have achieved remarkable success as
medicine, targeting both diagnostic and therapeutic applications associated with …

Recombinant antibodies for diagnostics and therapy against pathogens and toxins generated by phage display

P Kuhn, V Fühner, T Unkauf… - Proteomics–Clinical …, 2016 - Wiley Online Library
Antibodies are valuable molecules for the diagnostic and treatment of diseases caused by
pathogens and toxins. Traditionally, these antibodies are generated by hybridoma …

Cepharanthine inhibits dengue virus production and cytokine secretion

P Phumesin, J Panaampon, R Kariya, T Limjindaporn… - Virus Research, 2023 - Elsevier
Dengue virus (DENV) infection is a public health problem in tropical and subtropical regions.
It can cause a spectrum of clinical manifestations ranging from mild dengue fever (DF) to …

A peptide inhibitor derived from the conserved ectodomain region of DENV membrane (M) protein with activity against dengue virus infection

A Panya, N Sawasdee, M Junking… - Chemical biology & …, 2015 - Wiley Online Library
Dengue virus (DENV) infection is a public health problem worldwide; thus, the development
of a vaccine and anti‐DENV drugs is urgently needed. It has been observed that low levels …

Generation of recombinant antibodies against toxins and viruses by phage display for diagnostics and therapy

T Unkauf, S Miethe, V Fühner, T Schirrmann… - … , Selection and Activity of …, 2016 - Springer
Antibody phage display is an in vitro technology to generate recombinant antibodies. In
particular for pathogens like viruses or toxins, antibody phage display is an alternative to …

Discovery of a biological mechanism of active transport through the tympanic membrane to the middle ear

A Kurabi, KK Pak, M Bernhardt, A Baird, AF Ryan - Scientific Reports, 2016 - nature.com
Otitis media (OM) is a common pediatric disease for which systemic antibiotics are often
prescribed. While local treatment would avoid the systemic treatment side-effects, the …

[HTML][HTML] Clinacanthus nutans (Burm. f.) Lindau Extract Inhibits Dengue Virus Infection and Inflammation in the Huh7 Hepatoma Cell Line

K Jantakee, S Panwong, P Sattayawat, R Sumankan… - Antibiotics, 2024 - mdpi.com
Dengue virus (DENV) infection has emerged as a global health problem, with no specific
treatment available presently. Clinacanthus nutans (Burm. f.) Lindau extract has been used …

[HTML][HTML] Molecular docking NS4B of DENV 1-4 with known bioactive phyto-chemicals

A Paul, A Vibhuti, S Raj - Bioinformation, 2016 - ncbi.nlm.nih.gov
Dengue disease is a global disease that has no effective treatment. The dengue virus
(DENV) NS4B is a target for designing specific antivirals due to its importance in viral …

Functional properties of DENV EDIII-reactive antibodies in human DENV-1-infected sera and rabbit antiserum to EDIII

J Chen, K Wen, XQ Li, HS Yi… - Molecular …, 2016 - spandidos-publications.com
The envelope domain III (EDIII) of the dengue virus (DENV) has been confirmed to be
involved in receptor binding. It is the target of specific neutralizing antibodies, and is …