Background: Central nervous system (CNS) complications are among the most common,
devastating sequelae of sickle cell disease (SCD) occurring throughout the lifespan …

Purpose—The purpose of this statement is to review the literature on childhood stroke and to
provide recommendations for optimal diagnosis and treatment. This statement is intended …

With advances in brain imaging and completion of randomized clinical trials (RCTs) for
primary and secondary stroke prevention, the natural history of central nervous system …

Stroke is a devastating complication of sickle cell anemia (SCA) with high recurrence if
untreated. Chronic transfusions reduce recurrent strokes but have associated morbidities …

This chapter about antithrombotic therapy in neonates and children is part of the
Antithrombotic and Thrombolytic Therapy: American College of Chest Physicians Evidence …

A single amino acid substitution in hemoglobin comprises the molecular basis for sickle cell
anemia, but evolution of the corresponding clinical disease is extraordinarily complicated …

Over the past 40 years, public health measures such as universal newborn screening,
penicillin prophylaxis, vaccinations, and hydroxyurea therapy have led to an impressive …

The root cause of sickle cell disease is a single β‐globin gene mutation coding for the sickle
β‐hemoglobin chain. Sickle hemoglobin tetramers polymerize when deoxygenated …

Sickle cell disease is the most common cause of stroke in childhood, both ischaemic and
haemorrhagic, and it also affects adults with the condition. Without any screening or …

The sickle hemoglobin is an abnormal hemoglobin due to point mutation (GAG→ GTG) in
exon 1 of the β globin gene resulting in the substitution of glutamic acid by valine at position …