[HTML][HTML] Redox metabolism: ROS as specific molecular regulators of cell signaling and function
C Lennicke, HM Cochemé - Molecular Cell, 2021 - cell.com
Redox reactions are intrinsically linked to energy metabolism. Therefore, redox processes
are indispensable for organismal physiology and life itself. The term reactive oxygen species …
are indispensable for organismal physiology and life itself. The term reactive oxygen species …
[HTML][HTML] Functions of ROS in macrophages and antimicrobial immunity
M Herb, M Schramm - Antioxidants, 2021 - mdpi.com
Reactive oxygen species (ROS) are a chemically defined group of reactive molecules
derived from molecular oxygen. ROS are involved in a plethora of processes in cells in all …
derived from molecular oxygen. ROS are involved in a plethora of processes in cells in all …
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
Abstract 'Reactive oxygen species'(ROS) is an umbrella term for an array of derivatives of
molecular oxygen that occur as a normal attribute of aerobic life. Elevated formation of the …
molecular oxygen that occur as a normal attribute of aerobic life. Elevated formation of the …
[HTML][HTML] Superoxide radicals in the execution of cell death
J Fujii, T Homma, T Osaki - Antioxidants, 2022 - mdpi.com
Superoxide is a primary oxygen radical that is produced when an oxygen molecule receives
one electron. Superoxide dismutase (SOD) plays a primary role in the cellular defense …
one electron. Superoxide dismutase (SOD) plays a primary role in the cellular defense …
[HTML][HTML] Neuroprotective effect of antioxidants in the brain
KH Lee, M Cha, BH Lee - International journal of molecular sciences, 2020 - mdpi.com
The brain is vulnerable to excessive oxidative insults because of its abundant lipid content,
high energy requirements, and weak antioxidant capacity. Reactive oxygen species (ROS) …
high energy requirements, and weak antioxidant capacity. Reactive oxygen species (ROS) …
Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway
J Zhang, CM Simpson, J Berner, HB Chong, J Fang… - Cell, 2023 - cell.com
Multiple anticancer drugs have been proposed to cause cell death, in part, by increasing the
steady-state levels of cellular reactive oxygen species (ROS). However, for most of these …
steady-state levels of cellular reactive oxygen species (ROS). However, for most of these …
[HTML][HTML] Mitochondrial iron–sulfur clusters: Structure, function, and an emerging role in vascular biology
Abstract Iron-sulfur (Fe–S) clusters are essential cofactors most commonly known for their
role mediating electron transfer within the mitochondrial respiratory chain. The Fe–S cluster …
role mediating electron transfer within the mitochondrial respiratory chain. The Fe–S cluster …
Mitochondria as a therapeutic target for common pathologies
MP Murphy, RC Hartley - Nature Reviews Drug Discovery, 2018 - nature.com
Although the development of mitochondrial therapies has largely focused on diseases
caused by mutations in mitochondrial DNA or in nuclear genes encoding mitochondrial …
caused by mutations in mitochondrial DNA or in nuclear genes encoding mitochondrial …
[HTML][HTML] Cadmium-induced kidney injury: Oxidative damage as a unifying mechanism
LJ Yan, DC Allen - Biomolecules, 2021 - mdpi.com
Cadmium is a nonessential metal that has heavily polluted the environment due to human
activities. It can be absorbed into the human body via the gastrointestinal tract, respiratory …
activities. It can be absorbed into the human body via the gastrointestinal tract, respiratory …
[HTML][HTML] Generation of reactive oxygen species by mitochondria
P Hernansanz-Agustín, JA Enríquez - Antioxidants, 2021 - mdpi.com
Reactive oxygen species (ROS) are series of chemical products originated from one or
several electron reductions of oxygen. ROS are involved in physiology and disease and can …
several electron reductions of oxygen. ROS are involved in physiology and disease and can …