Expanding role of type II secretion in bacterial pathogenesis and beyond

NP Cianciotto, RC White - Infection and immunity, 2017 - Am Soc Microbiol
ABSTRACT Type II secretion (T2S) is one means by which Gram-negative pathogens
secrete proteins into the extracellular milieu and/or host organisms. Based upon recent …

Vibrio pathogens and their toxins in aquaculture: A comprehensive review

M Vandeputte, MA Kashem, P Bossier… - Reviews in …, 2024 - Wiley Online Library
Aquaculture is an indispensable food source for the growing world population. In the last
decades, its intensification has increased the incidence of viral and bacterial infections …

LuxR homologue SmcR is essential for Vibrio vulnificus pathogenesis and biofilm detachment, and its expression is induced by host cells

SM Kim, JH Park, HS Lee, WB Kim, JM Ryu… - Infection and …, 2013 - Am Soc Microbiol
Quorum sensing is a cell-to-cell communication system known to control many bacterial
processes. In the present study, the functions of quorum sensing in the pathogenesis of …

Identification and characterization of Vibrio vulnificus plpA encoding a phospholipase A2 essential for pathogenesis

KK Jang, ZW Lee, B Kim, YH Jung, HJ Han… - Journal of Biological …, 2017 - ASBMB
The marine bacterium Vibrio vulnificus causes food-borne diseases, which may lead to life-
threatening septicemia in some individuals. Therefore, identifying virulence factors in V …

Structure and assembly of pilotin-dependent and-independent secretins of the type II secretion system

SP Howard, LF Estrozi, Q Bertrand… - PLoS …, 2019 - journals.plos.org
The type II secretion system (T2SS) is a cell envelope-spanning macromolecular complex
that is prevalent in Gram-negative bacterial species. It serves as the predominant virulence …

Regulation of haemolysin (VvhA) production by ferric uptake regulator (Fur) in Vibrio vulnificus: repression of vvhA transcription by Fur and proteolysis of VvhA by Fur …

HJ Lee, JA Kim, MA Lee, SJ Park… - Molecular …, 2013 - Wiley Online Library
VvhA produced by V ibrio vulnificus exhibits cytolytic activity to human cells including
erythrocytes. Since haemolysis by VvhA may provide iron for bacterial growth and …

VvpM, an extracellular metalloprotease of Vibrio vulnificus, induces apoptotic death of human cells

MA Lee, JA Kim, YJ Yang, MY Shin, SJ Park… - Journal of …, 2014 - Springer
A pathogenic bacterium, Vibrio vulnificus produces various extracellular proteases including
the elastolytic metalloprotease, VvpE. In silico analysis of its genome revealed a VvpE …

OpaR and RpoS are positive regulators of a virulence factor PrtA in Vibrio parahaemolyticus

SC Chang, CY Lee - Microbiology, 2018 - microbiologyresearch.org
PrtA is an extracellular serine protease of Vibrio parahaemolyticus and has haemolytic and
cytotoxic activities. Many extracellular proteases have been shown to be required for nutrient …

Distinct characteristics of two 2-Cys peroxiredoxins of Vibrio vulnificus suggesting differential roles in detoxifying oxidative stress

YJ Bang, MH Oh, SH Choi - Journal of Biological Chemistry, 2012 - ASBMB
Peroxiredoxins (Prxs) are ubiquitous antioxidant enzymes reducing toxic peroxides. Two
distinct 2-Cys Prxs, Prx1 and Prx2, were identified in Vibrio vulnificus, a facultative aerobic …

Stationary‐phase induction of vvpS expression by three transcription factors: repression by LeuO and activation by SmcR and CRP

JA Kim, JH Park, MA Lee, HJ Lee, SJ Park… - Molecular …, 2015 - Wiley Online Library
An exoprotease of V ibrio vulnificus, VvpS, exhibits an autolytic function during the stationary
phase. To understand how vvpS expression is controlled, the regulators involved in vvpS …