Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in
embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin …
embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin …
Molecular Mechanism of Helicobacter pylori-Induced Gastric Cancer
M Alipour - Journal of gastrointestinal cancer, 2021 - Springer
Introduction Various types of cancers threaten human life. The role of bacteria in causing
cancer is controversial, but it has been determined that the Helicobacter pylori infection is …
cancer is controversial, but it has been determined that the Helicobacter pylori infection is …
The dialogue between neuroinflammation and adult neurogenesis: mechanisms involved and alterations in neurological diseases
Adult neurogenesis occurs mainly in the subgranular zone of the hippocampal dentate gyrus
and the subventricular zone of the lateral ventricles. Evidence supports the critical role of …
and the subventricular zone of the lateral ventricles. Evidence supports the critical role of …
Parkinson's disease, aging and adult neurogenesis: Wnt/β‐catenin signalling as the key to unlock the mystery of endogenous brain repair
B Marchetti, C Tirolo, F L'Episcopo, S Caniglia… - Aging cell, 2020 - Wiley Online Library
A common hallmark of age‐dependent neurodegenerative diseases is an impairment of
adult neurogenesis. Wingless‐type mouse mammary tumor virus integration site (Wnt)/β …
adult neurogenesis. Wingless‐type mouse mammary tumor virus integration site (Wnt)/β …
The role of astrocytes in the neurorepair process
RA Chiareli, GA Carvalho, BL Marques… - Frontiers in cell and …, 2021 - frontiersin.org
Astrocytes are highly specialized glial cells responsible for trophic and metabolic support of
neurons. They are associated to ionic homeostasis, the regulation of cerebral blood flow and …
neurons. They are associated to ionic homeostasis, the regulation of cerebral blood flow and …
The role of NURR1 in metabolic abnormalities of Parkinson's disease
M Al-Nusaif, Y Yang, S Li, C Cheng, W Le - Molecular neurodegeneration, 2022 - Springer
A constant metabolism and energy supply are crucial to all organs, particularly the brain.
Age-dependent neurodegenerative diseases, such as Parkinson's disease (PD), are …
Age-dependent neurodegenerative diseases, such as Parkinson's disease (PD), are …
Neuropilin-1 promotes mitochondrial structural repair and functional recovery in rats with cerebral ischemia
T Guo, M Chen, J Liu, Z Wei, J Yuan, W Wu… - Journal of translational …, 2023 - Springer
Objectives Available literature documents that ischemic stroke can disrupt the morphology
and function of mitochondria and that the latter in other disease models can be preserved by …
and function of mitochondria and that the latter in other disease models can be preserved by …
Triaging between post-translational modification of cell cycle regulators and their therapeutics in neurodegenerative diseases
Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and
Huntington's disease, present challenges in healthcare because of their complicated …
Huntington's disease, present challenges in healthcare because of their complicated …
[HTML][HTML] Small molecules from natural products targeting the Wnt/β-catenin pathway as a therapeutic strategy
D Liu, L Chen, H Zhao, ND Vaziri, SC Ma… - Biomedicine & …, 2019 - Elsevier
The Wnt/β-catenin signaling pathway is an evolutionarily conserved developmental
signaling event that plays a critical role in regulating tissue development and maintaining …
signaling event that plays a critical role in regulating tissue development and maintaining …
The scaffold protein AXIN1: gene ontology, signal network, and physiological function
L Qiu, Y Sun, H Ning, G Chen, W Zhao… - Cell Communication and …, 2024 - Springer
AXIN1, has been initially identified as a prominent antagonist within the WNT/β-catenin
signaling pathway, and subsequently unveiled its integral involvement across a diverse …
signaling pathway, and subsequently unveiled its integral involvement across a diverse …