Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities

J Liu, Q Xiao, J Xiao, C Niu, Y Li, X Zhang… - Signal transduction and …, 2022 - nature.com
The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in
embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin …

Molecular Mechanism of Helicobacter pylori-Induced Gastric Cancer

M Alipour - Journal of gastrointestinal cancer, 2021 - Springer
Introduction Various types of cancers threaten human life. The role of bacteria in causing
cancer is controversial, but it has been determined that the Helicobacter pylori infection is …

The dialogue between neuroinflammation and adult neurogenesis: mechanisms involved and alterations in neurological diseases

M Amanollahi, M Jameie, A Heidari, N Rezaei - Molecular neurobiology, 2023 - Springer
Adult neurogenesis occurs mainly in the subgranular zone of the hippocampal dentate gyrus
and the subventricular zone of the lateral ventricles. Evidence supports the critical role of …

Parkinson's disease, aging and adult neurogenesis: Wnt/β‐catenin signalling as the key to unlock the mystery of endogenous brain repair

B Marchetti, C Tirolo, F L'Episcopo, S Caniglia… - Aging cell, 2020 - Wiley Online Library
A common hallmark of age‐dependent neurodegenerative diseases is an impairment of
adult neurogenesis. Wingless‐type mouse mammary tumor virus integration site (Wnt)/β …

The role of astrocytes in the neurorepair process

RA Chiareli, GA Carvalho, BL Marques… - Frontiers in cell and …, 2021 - frontiersin.org
Astrocytes are highly specialized glial cells responsible for trophic and metabolic support of
neurons. They are associated to ionic homeostasis, the regulation of cerebral blood flow and …

The role of NURR1 in metabolic abnormalities of Parkinson's disease

M Al-Nusaif, Y Yang, S Li, C Cheng, W Le - Molecular neurodegeneration, 2022 - Springer
A constant metabolism and energy supply are crucial to all organs, particularly the brain.
Age-dependent neurodegenerative diseases, such as Parkinson's disease (PD), are …

Neuropilin-1 promotes mitochondrial structural repair and functional recovery in rats with cerebral ischemia

T Guo, M Chen, J Liu, Z Wei, J Yuan, W Wu… - Journal of translational …, 2023 - Springer
Objectives Available literature documents that ischemic stroke can disrupt the morphology
and function of mitochondria and that the latter in other disease models can be preserved by …

Triaging between post-translational modification of cell cycle regulators and their therapeutics in neurodegenerative diseases

N Rani, M Sahu, RK Ambasta, P Kumar - Ageing Research Reviews, 2024 - Elsevier
Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and
Huntington's disease, present challenges in healthcare because of their complicated …

[HTML][HTML] Small molecules from natural products targeting the Wnt/β-catenin pathway as a therapeutic strategy

D Liu, L Chen, H Zhao, ND Vaziri, SC Ma… - Biomedicine & …, 2019 - Elsevier
The Wnt/β-catenin signaling pathway is an evolutionarily conserved developmental
signaling event that plays a critical role in regulating tissue development and maintaining …

The scaffold protein AXIN1: gene ontology, signal network, and physiological function

L Qiu, Y Sun, H Ning, G Chen, W Zhao… - Cell Communication and …, 2024 - Springer
AXIN1, has been initially identified as a prominent antagonist within the WNT/β-catenin
signaling pathway, and subsequently unveiled its integral involvement across a diverse …