Oxidative stress in human pathology and aging: molecular mechanisms and perspectives

YA Hajam, R Rani, SY Ganie, TA Sheikh, D Javaid… - Cells, 2022 - mdpi.com
Reactive oxygen and nitrogen species (RONS) are generated through various endogenous
and exogenous processes; however, they are neutralized by enzymatic and non-enzymatic …

Oxidative stress mitigation by antioxidants-an overview on their chemistry and influences on health status

AM Pisoschi, A Pop, F Iordache, L Stanca… - European Journal of …, 2021 - Elsevier
The present review paper focuses on the chemistry of oxidative stress mitigation by
antioxidants. Oxidative stress is understood as a lack of balance between the pro-oxidant …

ROS generation and antioxidant defense systems in normal and malignant cells

AV Snezhkina, AV Kudryavtseva… - Oxidative medicine …, 2019 - Wiley Online Library
Reactive oxygen species (ROS) are by‐products of normal cell activity. They are produced
in many cellular compartments and play a major role in signaling pathways. Overproduction …

Mechanism of ferroptosis and its role in type 2 diabetes mellitus

W Sha, F Hu, Y Xi, Y Chu, S Bu - Journal of diabetes research, 2021 - Wiley Online Library
Ferroptosis is a novel form of nonapoptotic regulated cell death (RCD). It features iron‐
dependent lipid peroxide accumulation accompanied by inadequate redox enzymes …

Oxidative stress, inflammation and colorectal cancer: an overview

A Bardelčíková, J Šoltys, J Mojžiš - Antioxidants, 2023 - mdpi.com
Colorectal cancer (CRC) represents the second leading cause of cancer-related deaths
worldwide. The pathogenesis of CRC is a complex multistep process. Among other factors …

Antioxidants maintain cellular redox homeostasis by elimination of reactive oxygen species

L He, T He, S Farrar, L Ji, T Liu, X Ma - Cellular Physiology and …, 2017 - karger.com
Reactive oxygen species (ROS) are produced by living cells as normal cellular metabolic
byproduct. Under excessive stress conditions, cells will produce numerous ROS, and the …

[HTML][HTML] Molecular pathways associated with oxidative stress in diabetes mellitus

OM Ighodaro - Biomedicine & pharmacotherapy, 2018 - Elsevier
The role of oxidative stress in the occurrence and development of diabetes mellitus is both
critical and pivotal. Several molecular event cascade in different metabolic pathways such …

Prevalence of exposure of heavy metals and their impact on health consequences

K Rehman, F Fatima, I Waheed… - Journal of cellular …, 2018 - Wiley Online Library
Even in the current era of growing technology, the concentration of heavy metals present in
drinking water is still not within the recommended limits as set by the regulatory authorities in …

Molecular mechanisms of ROS production and oxidative stress in diabetes

P Newsholme, VF Cruzat, KN Keane… - Biochemical …, 2016 - portlandpress.com
Oxidative stress and chronic inflammation are known to be associated with the development
of metabolic diseases, including diabetes. Oxidative stress, an imbalance between oxidative …

[HTML][HTML] Chronic hyperglycemia mediated physiological alteration and metabolic distortion leads to organ dysfunction, infection, cancer progression and other …

B Giri, S Dey, T Das, M Sarkar, J Banerjee… - Biomedicine & …, 2018 - Elsevier
Chronic exposure of glucose rich environment creates several physiological and
pathophysiological changes. There are several pathways by which hyperglycemia …