Mammalian genomes express two principal gene categories through RNA polymerase II-
mediated transcription: protein-coding transcription units and non-coding RNA transcription …

Plants have an extraordinary diversity of transcription machineries, including five nuclear
DNA-dependent RNA polymerases. Four of these enzymes are dedicated to the production …

As sessile organisms, plants have evolved sophisticated ways to constantly gauge and
adapt to changing environmental conditions including extremes that may be harmful to their …

Temperature profoundly affects the kinetics of biochemical reactions, yet how large
molecular complexes such as the transcription machinery accommodate changing …

Plants monitor many aspects of their fluctuating environments to help align their
development with seasons. Molecular understanding of how noisy temperature cues are …

Histone chaperones and chromatin remodelers control nucleosome dynamics, which are
essential for transcription, replication, and DNA repair. The histone chaperone Anti …

How the noncoding genome affects cellular functions is a key biological question. A
particular challenge is to distinguish the effects of noncoding DNA elements from long …

The activities of RNA polymerases shape the epigenetic landscape of genomes with
profound consequences for genome integrity and gene expression. A fundamental event …

Transcriptional elongation by RNA polymerase II (RNAPII) through chromatin is a dynamic
and highly regulated step of eukaryotic gene expression. A combination of transcript …

Integrator is a multi-subunit protein complex associated with RNA polymerase II (Pol II), with
critical roles in noncoding RNA 3′-end processing and transcription attenuation of a broad …