Renal cell carcinoma as a metabolic disease: an update on main pathways, potential biomarkers, and therapeutic targets

NA di Meo, F Lasorsa, M Rutigliano, D Loizzo… - International Journal of …, 2022 - mdpi.com
Clear cell renal cell carcinoma (ccRCC) is the most frequent histological kidney cancer
subtype. Over the last decade, significant progress has been made in identifying the genetic …

Immune checkpoint inhibitors in renal cell carcinoma: molecular basis and rationale for their use in clinical practice

F Lasorsa, NA di Meo, M Rutigliano, M Milella, M Ferro… - Biomedicines, 2023 - mdpi.com
Renal cell carcinoma (RCC) is the seventh most common cancer in men and the ninth most
common cancer in women worldwide. There is plenty of evidence about the role of the …

Radiogenomics in renal cancer management—current evidence and future prospects

M Ferro, G Musi, M Marchioni, M Maggi… - International journal of …, 2023 - mdpi.com
Renal cancer management is challenging from diagnosis to treatment and follow-up. In
cases of small renal masses and cystic lesions the differential diagnosis of benign or …

Cellular and molecular players in the tumor microenvironment of renal cell carcinoma

F Lasorsa, M Rutigliano, M Milella, M Ferro… - Journal of Clinical …, 2023 - mdpi.com
Globally, clear-cell renal cell carcinoma (ccRCC) represents the most prevalent type of
kidney cancer. Surgery plays a key role in the treatment of this cancer, although one third of …

The use of immune checkpoint inhibitors in oncology and the occurrence of AKI: where do we stand?

R Franzin, GS Netti, F Spadaccino, C Porta… - Frontiers in …, 2020 - frontiersin.org
Immune checkpoint inhibitors (ICIs) are a novel class of immunotherapy drugs that have
improved the treatment of a broad spectrum of cancers as metastatic melanoma, non-small …

Cancer stem cells in renal cell carcinoma: origins and biomarkers

F Lasorsa, M Rutigliano, M Milella, M Ferro… - International Journal of …, 2023 - mdpi.com
The term “cancer stem cell”(CSC) refers to a cancer cell with the following features:
clonogenic ability, the expression of stem cell markers, differentiation into cells of different …

MUC1 expression affects the immunoflogosis in renal cell carcinoma microenvironment through complement system activation and immune infiltrate modulation

G Lucarelli, GS Netti, M Rutigliano, F Lasorsa… - International Journal of …, 2023 - mdpi.com
Mucin1 (MUC1), a glycoprotein associated with an aggressive cancer phenotype and
chemoresistance, is aberrantly overexpressed in a subset of clear cell renal cell carcinoma …

Metabolomic approaches for detection and identification of biomarkers and altered pathways in bladder cancer

NA di Meo, D Loizzo, SD Pandolfo, R Autorino… - International Journal of …, 2022 - mdpi.com
Metabolomic analysis has proven to be a useful tool in biomarker discovery and the
molecular classification of cancers. In order to find new biomarkers, and to better understand …

[HTML][HTML] PTX3 modulates the immunoflogosis in tumor microenvironment and is a prognostic factor for patients with clear cell renal cell carcinoma

GS Netti, G Lucarelli, F Spadaccino… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Abstract Pentraxin-3 (PTX3) belongs to the pentraxine family, innate immune regulators
involved in angiogenesis, proliferation and immune escape in cancer. Here, we evaluated …

The uniqueness of clear cell renal cell carcinoma: summary of the process and abnormality of glucose metabolism and lipid metabolism in ccRCC

X Qi, Q Li, X Che, Q Wang, G Wu - Frontiers in Oncology, 2021 - frontiersin.org
Kidney cancer is a cancer with an increasing incidence in recent years. Clear cell renal cell
carcinoma (ccRCC) accounts for up to 80% of all kidney cancers. The understanding of the …