Apoptosis has been established as a mechanism of anti-cancer defense. Members of the
BCL-2 family are critical mediators of apoptotic cell death in health and disease, often found …

Apocrine change occurs in a spectrum of benign lesions in the female breast and is also
demonstrated in a subgroup of in situ and invasive carcinomas. Recent research has …

We have generated DNA methylation profiles of 148 human breast tumors and found
significant differences in hormone receptor (HR) status between clusters of DNA methylation …

Glutathione S-transferase pi (GST-pi), a Phase II detoxification enzyme, has recently been
implicated in protection against apoptosis. Expression of GST-pi and Bcl-2 protein, an …

Multiple clinical studies have correlated gene expression with survival outcome in cancer on
a genome-wide scale. However, in many cases, no obvious correlation between expression …

The expression of transcripts for anti-apoptotic (survivin, survivin-ΔEx3, survivin-2B, galectin-
3, bag-1 and bcl-2) and pro-apoptotic (bax-α) genes, and for multiple drug resistance related …

We have previously demonstrated that the anti-apoptotic protein BAD is expressed in normal
human breast tissue and shown that BAD inhibits expression of cyclin D1 to delay cell-cycle …

The purpose of this work was to determine if the immunohistochemical p53 (+) Bcl‐2 (−)
phenotype predicts survival in breast cancer patients. Tissue from 819 cases of resected …

Patients with tumors expressing promoters of apoptosis (bax) versus inhibitors of apoptosis
(bcl-2, bcl-x) may have increased survival. The purpose of this study was to determine the …

Context.—Dysregulated cell proliferation caused by inhibitors of programmed cell death
(apoptosis) contributes to tumor progression and spread. Aberrant expression of Bcl-2, the …