In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway,
termed the integrated stress response (ISR), to restore cellular homeostasis. The core event …

Activating transcription factor 4 (ATF4) is a stress-induced transcription factor that is
frequently upregulated in cancer cells. ATF4 controls the expression of a wide range of …

Autophagy is an evolutionarily conserved catabolic mechanism, by which eukaryotic cells
recycle or degrades internal constituents through membrane-trafficking pathway. Thus …

An accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) leads
to stress conditions. To mitigate such circumstances, stressed cells activate a homeostatic …

Multiple myeloma (MM) is the second most common blood cancer. Treatments for MM
include corticosteroids, alkylating agents, anthracyclines, proteasome inhibitors …

Cancer-specific inhibitors that reflect the unique metabolic needs of cancer cells are rare.
Here we describe Gboxin, a small molecule that specifically inhibits the growth of primary …

Autophagy is an evolutionarily conserved process in eukaryotes that eliminates harmful
components and maintains cellular homeostasis in response to a series of extracellular …

Autophagy is a tightly regulated pathway involving the lysosomal degradation of cytoplasmic
organelles or cytosolic components. This pathway can be stimulated by multiple forms of …

The integrated stress response (ISR) is an evolutionarily conserved intra-cellular signaling
network which is activated in response to intrinsic and extrinsic stresses. Various stresses …

Autophagy is a conserved process by which cytoplasmic components are degraded by the
lysosome. It is commonly seen as a cytoplasmic event and, until now, nuclear events were …