Hypertension, particularly midlife high blood pressure, has been related to a higher risk of
cognitive decline and dementia, including Alzheimer disease. However, these associations …

Alzheimer's disease (AD) is the most common cause of dementia and there is currently no
cure. Novel approaches to treat AD and curb the rapidly increasing worldwide prevalence …

Background: Cerebrovascular disease is a common comorbidity in patients with Alzheimer's
disease (AD). It is believed to contribute additively to the cognitive impairment and to lower …

Alzheimer disease (AD) is the most common cause of dementia. Biological definitions of AD
are limited to the cerebral burden of amyloid β plaques, neurofibrillary pathology, and …

Background Chronic cerebral hypoperfusion (CCH) causes white matter damage and
cognitive impairment, in which astrogliosis is the major pathology. However, underlying …

BACKGROUND: It is unknown whether hypertension plays any role in cerebral myelination.
To fill this knowledge gap, we studied 90 cognitively unimpaired adults, age range 40 to 94 …

BACKGROUND: Microvascular function in the brain and heart may play an important role in
the course of patients with heart failure (HF), but its relationship with ventricular and …

Background Aortic stiffness is closely linked with cardiovascular diseases (CVDs), but recent
studies suggest that it is also a risk factor for cognitive decline and dementia. However, the …

The sources of inter-and intra-individual variability in age-related cognitive decline remain
poorly understood. We examined the association between 20-year trajectories of cognitive …

Arterial spin labeling (ASL) can be used to detect differences in perfusion for multiple brain
regions thought to be important in major depressive disorder (MDD). However, the potential …