Impairments of vision and hearing are highly prevalent conditions limiting the quality of life
and presenting a major socioeconomic burden. For a long time, retinal and cochlear …

Abstract Adeno-associated virus (AAV)-mediated inner ear gene therapy is a promising
treatment option for hearing loss and dizziness. Several studies have shown that AAV …

The use of viral vectors for inner ear gene therapy is receiving increased attention for
treatment of genetic hearing disorders. Most animal studies to date have injected viral …

Dizziness and hearing loss are among the most common disabilities. Many forms of
hereditary balance and hearing disorders are caused by abnormal development of …

Local delivery of therapeutic drugs into the inner ear is a promising therapy for inner ear
diseases. Injection through semicircular canals (canalostomy) has been shown to be a …

Abstract Characterization of adeno-associated viral vector (AAV) mediated gene delivery to
the enteric nervous system (ENS) was recently described in mice and rats. In these proof-of …

Adeno-associated virus (AAV)-mediated gene transfer is an efficient method of gene over-
expression in the vestibular end organs. However, AAV has limited usefulness for delivering …

Over the last decade, pioneering molecular gene therapy for inner-ear disorders have
achieved experimental hearing improvements after a single local or systemic injection of …

Viral-mediated gene augmentation, silencing, or editing offers tremendous promise for the
treatment of inherited and acquired deafness. Inner-ear gene therapies often require a safe …

JCI Insight - Extended time frame for restoring inner ear function through gene therapy in
Usher1G preclinical model Go to The Journal of Clinical Investigation About Editors Consulting …