[PDF][PDF] Review on epidermal growth factor receptor (EGFR) structure, signaling pathways, interactions, and recent updates of EGFR inhibitors
The epidermal growth factor receptor (EGFR) belongs to the ERBB family of tyrosine kinase
receptors. EGFR signaling cascade is a key regulator in cell proliferation, differentiation …
receptors. EGFR signaling cascade is a key regulator in cell proliferation, differentiation …
Globally approved EGFR inhibitors: Insights into their syntheses, target kinases, biological activities, receptor interactions, and metabolism
Targeting the EGFR with small-molecule inhibitors is a confirmed valid strategy in cancer
therapy. Since the FDA approval of the first EGFR-TKI, erlotinib, great efforts have been …
therapy. Since the FDA approval of the first EGFR-TKI, erlotinib, great efforts have been …
Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy
Surgical resection of solid tumors is currently the gold standard and preferred therapeutic
strategy for cancer. Chemotherapy drugs also make a significant contribution by inhibiting …
strategy for cancer. Chemotherapy drugs also make a significant contribution by inhibiting …
Advances in covalent kinase inhibitors
A Abdeldayem, YS Raouf, SN Constantinescu… - Chemical Society …, 2020 - pubs.rsc.org
Over the past decade, covalent kinase inhibitors (CKI) have seen a resurgence in drug
discovery. Covalency affords a unique set of advantages as well as challenges relative to …
discovery. Covalency affords a unique set of advantages as well as challenges relative to …
Worldwide prevalence of epidermal growth factor receptor mutations in non-small cell lung cancer: a meta-analysis
B Melosky, K Kambartel, M Haentschel… - Molecular Diagnosis & …, 2022 - Springer
Background Identification of variable epidermal growth factor receptor (EGFR) gene
mutations in non-small cell lung cancer (NSCLC) is important for the selection of appropriate …
mutations in non-small cell lung cancer (NSCLC) is important for the selection of appropriate …
The latest battles between EGFR monoclonal antibodies and resistant tumor cells
WQ Cai, LS Zeng, LF Wang, YY Wang, JT Cheng… - Frontiers in …, 2020 - frontiersin.org
Epidermal growth factor receptor (EGFR) is a tyrosine kinase receptor involved in
homeostatic regulation of normal cells and carcinogenesis of epithelial malignancies. With …
homeostatic regulation of normal cells and carcinogenesis of epithelial malignancies. With …
Tumor targeting strategies of smart fluorescent nanoparticles and their applications in cancer diagnosis and treatment
Advantages such as strong signal strength, resistance to photobleaching, tunable
fluorescence emissions, high sensitivity, and biocompatibility are the driving forces for the …
fluorescence emissions, high sensitivity, and biocompatibility are the driving forces for the …
[HTML][HTML] Mechanisms of drug resistance in colon cancer and its therapeutic strategies
Drug resistance develops in nearly all patients with colon cancer, leading to a decrease in
the therapeutic efficacies of anticancer agents. This review provides an up-to-date summary …
the therapeutic efficacies of anticancer agents. This review provides an up-to-date summary …
Self-attention based molecule representation for predicting drug-target interaction
Predicting drug-target interactions (DTI) is an essential part of the drug discovery process,
which is an expensive process in terms of time and cost. Therefore, reducing DTI cost could …
which is an expensive process in terms of time and cost. Therefore, reducing DTI cost could …
The epidermal growth factor network: role in oocyte growth, maturation and developmental competence
D Richani, RB Gilchrist - Human reproduction update, 2018 - academic.oup.com
BACKGROUND The LH surge induces great physiological changes within the preovulatory
follicle, which culminate in the ovulation of a mature oocyte that is capable of supporting …
follicle, which culminate in the ovulation of a mature oocyte that is capable of supporting …