ABSTRACT Approximately 4.4% of the human genome is comprised of endogenous
retroviral sequences, a record of an evolutionary battle between man and retroviruses. Much …

It is well established that CD4+ T cells play an important role in immunity to infections with
retroviruses such as HIV. However, in recent years CD4+ T cells have been subdivided into …

The T cell-dependent B cell response relies on cognate interaction between B cells and
CD4+ Th cells. However, the consequences of this interaction for CD4+ T cells are not …

Regulatory T cells (Tregs) are immunosuppressive cells of the immune system that control
autoimmune reactivity. Tregs also respond during immune reactions to infectious agents in …

ABSTRACT B cell follicles of the spleen and lymph nodes are immune privileged sites and
serve as sanctuaries for infected CD4+ cells in HIV infection. It is assumed that CD8+ T cell …

Major conceptual roadblocks impede the development of an HIV-1 vaccine that can
stimulate a potent neutralizing antibody response. Animal models that support HIV-1 …

Friend virus (FV) is a naturally occurring mouse retrovirus that infects dividing cells of the
hematopoietic lineage, including antigen-presenting cells (APCs). The infection of APCs by …

T cell immunity relies on the generation and maintenance of a diverse repertoire of T cell
antigen receptors (TCRs). The strength of signaling emanating from the TCR dictates the …

Antiretroviral neutralizing antibody (NAb) responses are often evaluated in the absence of
Fc-dependent immune effectors. In murine Friend retrovirus infection, Apobec3/Rfv3 …

Dendritic cells (DCs) express Fcγ receptors (FcγRs) for the binding immune complexes (ICs)
consisting of IgG and antigens (Ags). IC–FcγR interactions have been demonstrated to …