Growth hormone (GH) has been used for over 35 years, and its safety and efficacy has been
studied extensively. Experimental studies showing the permissive role of GH/insulin-like …

Growth hormone (GH) deficiency is a common pituitary hormone deficiency in childhood
cancer survivors (CCS). The identification, diagnosis, and treatment of those individuals at …

Purpose The physical properties of protons lower doses to surrounding normal tissues
compared with photons, potentially reducing acute and long-term adverse effects, including …

Background Childhood cancer survivors are at risk of subsequent gliomas and
meningiomas, but the risks beyond age 40 years are uncertain. We quantified these risks in …

Individuals surviving cancer and brain tumors may experience growth hormone (GH)
deficiency as a result of tumor growth, surgical resection and/or radiotherapy involving the …

Importance Meningioma is the most common subsequent neoplasm following cranial
irradiation among survivors of childhood cancer, but there are still uncertainties regarding …

At its very core, radiation oncology involves a trade-off between the benefits and risks of
exposing tumors and normal tissue to relatively high doses of ionizing radiation. This trade …

Albeit the effort to develop targeted therapies for patients with high-grade gliomas (WHO
grades III and IV) is evidenced by hundreds of current clinical trials, radiation remains one of …

Purpose A Pediatric Normal Tissue Effects in the Clinic (PENTEC) analysis of published
investigations of central nervous system (CNS) subsequent neoplasms (SNs), subsequent …

Purpose In this Pediatric Normal Tissue Effects in the Clinic (PENTEC) vision paper,
challenges and opportunities in the assessment of subsequent neoplasms (SNs) from …