[HTML][HTML] Neurotrophic factors in the physiology of motor neurons and their role in the pathobiology and therapeutic approach to amyotrophic lateral sclerosis

WM Stansberry, BA Pierchala - Frontiers in Molecular Neuroscience, 2023 - frontiersin.org
The discovery of the neurotrophins and their potent survival and trophic effects led to great
enthusiasm about their therapeutic potential to rescue dying neurons in neurodegenerative …

Loss of larger hypoglossal motor neurons in aged Fischer 344 rats

MJ Fogarty - Respiratory Physiology & Neurobiology, 2023 - Elsevier
The intrinsic (longitudinal, transversalis and verticalis) and extrinsic (genioglossus,
styloglossus, hyoglossus and geniohyoid) tongue muscles are innervated by hypoglossal …

Postnatal survival of phrenic motor neurons is promoted by BDNF/TrkB. FL signaling

JE Brandenburg, MJ Fogarty… - Journal of Applied …, 2024 - journals.physiology.org
The number of motor neurons (MNs) declines precipitously during the final trimester before
birth. Thereafter, the number of MNs remains relatively stable, with their connections to …

Size-dependent differences in mitochondrial volume density in phrenic motor neurons

MJ Fogarty, S Rana, CB Mantilla… - Journal of Applied …, 2023 - journals.physiology.org
Neuromotor control of diaphragm muscle (DIAm) motor units is dependent on an orderly size-
dependent recruitment of phrenic motor neurons (PhMNs). Slow (type S) and fast, fatigue …

Assessing Functional Recovery of Eupneic Diaphragm Activity Following Unilateral Cervical Spinal Cord Injury in Rats

OU Khurram, MJ Fogarty, WZ Zhan, CB Mantilla… - JoVE (Journal of …, 2024 - jove.com
Following cSCI, activation of the DIAm can be impacted depending on the extent of the
injury. The present manuscript describes a unilateral C2 hemisection (C2SH) model of cSCI …