Myeloid cells are pivotal within the immunosuppressive tumour microenvironment. The
accumulation of tumour-modified myeloid cells derived from monocytes or neutrophils …

The M1/M2 macrophage paradigm plays a key role in tumor progression. M1 macrophages
are historically regarded as anti-tumor, while M2-polarized macrophages, commonly …

Metastasis is the major cause of cancer death, and the development of therapy resistance is
common. The tumor microenvironment can confer chemotherapy resistance …

Therapeutic resistance continues to be an indominable foe in our ambition for curative
cancer treatment. Recent insights into the molecular determinants of acquired treatment …

The therapeutic effect of highly malignant triple negative breast cancer (TNBC) is negatively
affected by the formation of tumor cell resistant clone and the severe toxicity of …

The concept of nanoparticle transport through gaps between endothelial cells (inter-
endothelial gaps) in the tumour blood vessel is a central paradigm in cancer nanomedicine …

Tumor-associated macrophages (TAMs) promote metastasis and inhibit T cells, but
macrophages can be polarized to kill cancer cells. Macrophage polarization could thus be a …

Infiltration of macrophages in solid tumours is associated with poor prognosis and correlates
with chemotherapy resistance in most cancers. In mouse models of cancer, macrophages …

Tumours display considerable variation in the patterning and properties of angiogenic blood
vessels, as well as in their responses to anti-angiogenic therapy. Angiogenic programming …

Mortality from breast cancer is almost exclusively a result of tumor metastasis and resistance
to therapy and therefore understanding the underlying mechanisms is an urgent challenge …