Osteocytes, former osteoblasts encapsulated by mineralized bone matrix, are far from being
passive and metabolically inactive bone cells. Instead, osteocytes are multifunctional and …

After discovering that lack of Sost/sclerostin expression is the cause of the high bone mass
human syndromes Van Buchem disease and sclerosteosis, extensive animal …

Parathyroid hormone (PTH) exerts profound effects on skeletal homeostasis through
multiple cellular and molecular mechanisms. Continuous hyperparathyroidism causes net …

Teeth are attached to alveolar bone by the periodontal ligament (PDL), which contains stem
cells supporting tissue turnover. Here, we identified Gli1+ cells in adult mouse molar PDL as …

Osteoporosis is a skeletal disorder characterized by bone loss, which results in architectural
deterioration of the skeleton, compromised bone strength and an increased risk of fragility …

Wnt ligands play a central role in the development and homeostasis of various organs
through β-catenin-dependent and-independent signalling. The crucial roles of Wnt/β-catenin …

Wnt signaling executes an indispensable performance in osteoblast differentiation, bone
development, homeostasis, and remodeling. Wnt signals trigger the intracellular Wnt …

Osteocytes, entrapped within a newly mineralized bone matrix, possess a unique cellular
identity due to a specialized morphology and a molecular signature. These features endow …

Osteocytes are the most abundant cells in bone and are the major orchestrators of bone
remodeling and mineral homeostasis. They possess a specialized cellular morphology and …

The conversion of mechanical energy into biochemical changes within living cells is process
known as mechanotransduction. Bone is a quintessential tissue for studying the molecular …