Characterization of the tumor microenvironment through immunoprofiling has become an
essential resource for the understanding of the complex immune cell interactions and the …

Background Glioma is a prevalent and lethal brain malignancy; despite current treatment
options, the prognosis remains poor. Therefore, immunotherapy has emerged as a …

Background Metastasis is a major obstacle in the treatment of cervical cancer (CC), and
SPOP-mediated regulatory effects are involved in metastasis. However, the mechanisms …

Glioblastomas (GBM) are the most aggressive tumors originating in the brain.
Histopathologic features include circuitous, disorganized, and highly permeable blood …

To maintain the integrity of an organism, a well-functioning immune system is essential.
Immunity is dynamic, with constant surveillance needed to determine whether to initiate an …

Background The advantages of radiotherapy for head and neck squamous cell carcinoma
(HNSCC) depend on the radiation sensitivity of the patient. Here, we established and …

Current clinical factors for screening candidates that might benefit from adjuvant
chemotherapy in colon cancer are inadequate. Tumor microenvironment, especially the …

Brain tumours are the most common solid tumour in children and the leading cause of
cancer related death in children. Current treatments include surgery, chemotherapy and …

One of the most common cancers worldwide, primary liver cancer remains a major cause of
cancer-related mortality. Hepatocellular carcinoma and cholangiocarcinoma represent the …

The prognosis of pediatric central nervous system (CNS) malignancies remains dismal due
to limited treatment options, resulting in high mortality rates and long-term morbidities …