The common fruit fly, Drosophila melanogaster, is a well studied and highly tractable genetic
model organism for understanding molecular mechanisms of human diseases. Many basic …

Sleep and circadian rhythm disruption are frequently observed in patients with psychiatric
disorders and neurodegenerative disease. The abnormal sleep that is experienced by these …

J. Neurochem.(2011) 116, 1–9. Abstract Since its initial characterization over 20 years ago,
there has been intense and unwavering interest in understanding the role of the …

Recent advances in our understanding of the underlying genetic architecture of psychiatric
disorders has blown away the diagnostic boundaries that are defined by currently used …

The endoplasmic reticulum (ER) is an important organelle involved in cellular homeostasis
and control of protein quality. Unfolded protein response (UPR) is a cellular response to ER …

How might one determine whether simple animals such as flies sleep in stages? Sleep in
mammals is a dynamic process involving different stages of sleep intensity, and these are …

Schizophrenia (SZ) is primarily an adult psychiatric disorder in which disturbances caused
by susceptibility genes and environmental insults during early neurodevelopment initiate …

Shiftwork became common during the last few decades with the growing demands of human
life. Despite the social inactivity and irregularity in habits, working in continuous irregular …

In the decade since Disrupted in Schizophrenia 1 (DISC1) was first identified it has become
one of the most convincing risk genes for major mental illness. As a multi-functional scaffold …

The biology of schizophrenia is complex with multiple hypotheses (dopamine, glutamate,
neurodevelopmental) well supported to underlie the disease. Pathways centered on the risk …