An introduction to PIWI-interacting RNAs (piRNAs) in the context of metazoan small RNA silencing pathways
AD Haase - RNA biology, 2022 - Taylor & Francis
ABSTRACT PIWI proteins and their associated PIWI-interacting RNAs (piRNAs) constitute a
small RNA-based adaptive immune system that restricts the deleterious activity of mobile …
small RNA-based adaptive immune system that restricts the deleterious activity of mobile …
How genetic defects in piRNA trimming contribute to male infertility
JM Mann, C Wei, C Chen - Andrology, 2023 - Wiley Online Library
In germ cells, small non‐coding PIWI‐interacting RNAs (piRNAs) work to silence harmful
transposons to maintain genomic stability and regulate gene expression to ensure fertility …
transposons to maintain genomic stability and regulate gene expression to ensure fertility …
Themes and variations on piRNA-guided transposon control
Z Loubalova, P Konstantinidou, AD Haase - Mobile DNA, 2023 - Springer
PIWI-interacting RNAs (piRNAs) are responsible for preventing the movement of
transposable elements in germ cells and protect the integrity of germline genomes. In this …
transposable elements in germ cells and protect the integrity of germline genomes. In this …
A comparative roadmap of PIWI-interacting RNAs across seven species reveals insights into de novo piRNA-precursor formation in mammals
P Konstantinidou, Z Loubalova, F Ahrend, A Friman… - Cell Reports, 2024 - cell.com
PIWI-interacting RNAs (piRNAs) play a crucial role in safeguarding genome integrity by
silencing mobile genetic elements. From flies to humans, piRNAs originate from long single …
silencing mobile genetic elements. From flies to humans, piRNAs originate from long single …
[HTML][HTML] Target-specific requirements for RNA interference can arise through restricted RNA amplification despite the lack of specialized pathways
DR Knudsen-Palmer, P Raman, F Ettefa, L De Ravin… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Since double-stranded RNA (dsRNA) is effective for silencing a wide variety of genes, all
genes are typically considered equivalent targets for such RNA interference (RNAi). Yet …
genes are typically considered equivalent targets for such RNA interference (RNAi). Yet …
CRISPR‐Cas9 Genome Editing and Rapid Selection of Cell Pools
D Stoyko, TO, A Hernandez, P Konstantinidou… - Current …, 2022 - Wiley Online Library
The harnessing of the CRISPR‐Cas9 system allows for quick and inexpensive genome
editing in tissue culture models. Traditional CRISPR‐Cas9 genome editing techniques rely …
editing in tissue culture models. Traditional CRISPR‐Cas9 genome editing techniques rely …
Target-specific requirements for RNA interference can be explained by a single regulatory network
Since double-stranded RNA (dsRNA) is effective for silencing a wide variety of genes, all
genes are typically considered equivalent targets for such RNA interference (RNAi). Yet …
genes are typically considered equivalent targets for such RNA interference (RNAi). Yet …
Functional dissection of the piRNA pathway in adult neurogenesis and neuroinflammation
S Beatini - 2024 - tesidottorato.depositolegale.it
Piwi proteins and the small non-coding RNAs interacting with them (piRNAs), collectively
referred to as the piRNA pathway, are best known in gonads where they safeguard genomic …
referred to as the piRNA pathway, are best known in gonads where they safeguard genomic …