Targeting the endocannabinoid CB1 receptor to treat body weight disorders: a preclinical and clinical review of the therapeutic potential of past and present CB1 drugs
T Murphy, B Le Foll - Biomolecules, 2020 - mdpi.com
Obesity rates are increasing worldwide and there is a need for novel therapeutic treatment
options. The endocannabinoid system has been linked to homeostatic processes, including …
options. The endocannabinoid system has been linked to homeostatic processes, including …
Synthesis and biological evaluation of isatin oxime ether-tethered aryl 1 H-1, 2, 3-triazoles as inhibitors of Mycobacterium tuberculosis
SK Kancharla, S Birudaraju, A Pal, LK Reddy… - New Journal of …, 2022 - pubs.rsc.org
A series of fifteen novel isatin oxime ether-tethered aryl 1H-1, 2, 3-triazole hybrids 5a–o
were designed and synthesized by employing Cu (I) catalyzed azide–alkyne [3+ 2] …
were designed and synthesized by employing Cu (I) catalyzed azide–alkyne [3+ 2] …
The progress of small molecules against cannabinoid 2 receptor (CB2R)
Q Zhang, Y Zhao, J Wu, W Zhong, W Huang, Y Pan - Bioorganic Chemistry, 2024 - Elsevier
The two subtypes of cannabinoid receptors (CBR), namely CB 1 R and CB 2 R, belong to
the G protein-coupled receptor (GPCR) superfamily and are confirmed as potential …
the G protein-coupled receptor (GPCR) superfamily and are confirmed as potential …
Synthesis, characterization and antimicrobial evaluation of ferrocene–oxime ether benzyl 1 H-1, 2, 3-triazole hybrids
Y Swetha, ER Reddy, JR Kumar, R Trivedi… - New Journal of …, 2019 - pubs.rsc.org
A series of eight novel ferrocene–oxime ether benzyl 1H-1, 2, 3 triazole hybrids 5a–h were
designed and synthesized by employing Cu (I) catalyzed azide–alkyne [3+ 2] cycloaddition …
designed and synthesized by employing Cu (I) catalyzed azide–alkyne [3+ 2] cycloaddition …
Cobalt‐Catalyzed Multi‐Substituted Alkene Synthesis from 1, 3‐Dithiolanes and Grignard Reagents
TA Davidson, S Anam, H Shi… - Asian Journal of Organic …, 2023 - Wiley Online Library
The cobalt‐catalyzed reaction between 1, 3‐dithiolanes and Grignard reagents, for the
efficient synthesis of multi‐substituted alkene products, is described. The method was …
efficient synthesis of multi‐substituted alkene products, is described. The method was …
Improved cyclobutyl nabilone analogs as potent CB1 receptor agonists
IP Papanastasiou, MO Georgiadis… - European Journal of …, 2022 - Elsevier
In earlier work, we explored the SAR for the C3 side chain pharmacophore in the
hexahydrocannabinol template represented by the drug nabilone, which resulted in the …
hexahydrocannabinol template represented by the drug nabilone, which resulted in the …
Natural compounds and synthetic drugs to target type-1 cannabinoid (CB1) receptor
C Iliopoulos-Tsoutsouvas, MO Georgiadis, L Ji… - 2020 - books.rsc.org
Preparations of Cannabis sativa have been used in traditional medicine to treat various
conditions, such as pain, inflammation, and epilepsy, and for recreational purposes across …
conditions, such as pain, inflammation, and epilepsy, and for recreational purposes across …
Impact of Cannabinoid Receptors in the Design of Therapeutic Agents against Human Ailments
The Cannabinoid (CB) signalling cascade is widely located in the human body and is
associated with several pathophysiological processes. The endocannabinoid system …
associated with several pathophysiological processes. The endocannabinoid system …
The novel cannabinoid CB1 receptor agonist AM11101 increases food intake in female rats
SB Ogden, MS Malamas… - British Journal of …, 2019 - Wiley Online Library
Background and Purpose Δ9‐tetrahydrocannabinol (THC) acts via cannabinoid CB1
receptors to increase feeding. Here, we assessed the orexigenic effect of AM11101, a novel …
receptors to increase feeding. Here, we assessed the orexigenic effect of AM11101, a novel …
Natural Compounds and Synthetic Drugs to Target FAAH Enzyme
S Butini, S Gemma, G Campiani - 2020 - books.rsc.org
The fatty acid amide hydrolase (FAAH, EC 3.5. 1.99) is an integral intracellular membrane-
bound enzyme that was properly characterized in the mid-1980s, 1 although an N …
bound enzyme that was properly characterized in the mid-1980s, 1 although an N …