Obesity and its attendant metabolic disorders represent the great public health challenge of
our time. Recent evidence suggests that onset of inflammation in metabolic tissues …

Aims To update the evidence about the diabetogenic effect of statins. Methods We searched
for randomized-controlled trials reporting the effects of statin therapy on glycosylated …

Background Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to
assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3 …

Methods A total of 8,749 non-diabetic participants, aged 45–73 years, were followed up for
5.9 years. New diabetes was diagnosed in 625 men by means of an OGTT, HbA 1c≥ …

Background This study investigates whether the incidence of new-onset diabetes mellitus
(DM) is associated with statin use among postmenopausal women participating in the …

Objective: Statin treatment reduces the risk of atherosclerotic cardiovascular disease but is
associated with a modest increased risk of type 2 diabetes, especially in those with insulin …

Statins are the gold-standard treatment for the prevention of primary and secondary
cardiovascular disease, which is the leading cause of mortality worldwide. Despite the safety …

Abstract Treatment with statins has transformed primary and secondary prevention of
cardiovascular disease (CVD), including thrombotic stroke. Evidence-based data …

Objective Several clinical trials of cardiovascular disease prevention with statins have
reported increased risk of type 2 diabetes (T2DM) with statin therapy. However, participants …

New-onset diabetes has been observed in clinical trials and meta-analyses involving statin
therapy. To explain this association, three major mechanisms have been proposed and …