Mitofusins: disease gatekeepers and hubs in mitochondrial quality control by E3 ligases

M Escobar-Henriques, M Joaquim - Frontiers in physiology, 2019 - frontiersin.org
Mitochondria are dynamic organelles engaged in quality control and aging processes. They
constantly undergo fusion, fission, transport, and anchoring events, which empower …

E3 ubiquitin ligases neurobiological mechanisms: development to degeneration

A Upadhyay, V Joshi, A Amanullah, R Mishra… - Frontiers in molecular …, 2017 - frontiersin.org
Cells regularly synthesize new proteins to replace old or damaged proteins. Deposition of
various aberrant proteins in specific brain regions leads to neurodegeneration and aging …

Axon-seq decodes the motor axon transcriptome and its modulation in response to ALS

J Nijssen, J Aguila, R Hoogstraaten, N Kee, E Hedlund - Stem cell reports, 2018 - cell.com
Spinal motor axons traverse large distances to innervate target muscles, thus requiring local
control of cellular events for proper functioning. To interrogate axon-specific processes we …

A protein–miRNA biomic analysis approach to explore neuroprotective potential of nobiletin in human neural progenitor cells (hNPCs)

S Jahan, UA Ansari, AK Srivastava… - Frontiers in …, 2024 - frontiersin.org
Chemical-induced neurotoxicity is increasingly recognized to accelerate the development of
neurodegenerative disorders (NDs), which pose an increasing health burden to society …

A cerebrospinal fluid microRNA analysis: Progressive supranuclear palsy

W Nonaka, T Takata, H Iwama… - Molecular …, 2022 - spandidos-publications.com
Progressive supranuclear palsy (PSP) is a neurodegenerative tauopathy described as a
syndrome of postural instability, supranuclear vertical gaze palsy, dysarthria, dystonic rigidity …

Rare copy number variants analysis identifies novel candidate genes in heterotaxy syndrome patients with congenital heart defects

C Liu, R Cao, Y Xu, T Li, F Li, S Chen, R Xu, K Sun - Genome Medicine, 2018 - Springer
Abstract Background Heterotaxy (Htx) syndrome comprises a class of congenital disorders
resulting from malformations in left-right body patterning. Approximately 90% of patients with …

Cellular prion protein (PrPc): putative interacting partners and consequences of the interaction

H Miranzadeh Mahabadi, C Taghibiglou - International journal of …, 2020 - mdpi.com
Cellular prion protein (PrPc) is a small glycosylphosphatidylinositol (GPI) anchored protein
most abundantly found in the outer leaflet of the plasma membrane (PM) in the central …

Proteasome‐mediated proteostasis: novel medicinal and pharmacological strategies for diseases

R Mishra, A Upadhyay, VK Prajapati… - Medicinal research …, 2018 - Wiley Online Library
Proteins actively participate in a wide range of cellular physiological functions. But
aggregation of proteins results in cytotoxicity, and unwanted aggregation of misfolded …

Transcriptome sequencing analysis of circRNA in skeletal muscle between fast-and slow-growing chickens at embryonic stages

G Zhang, J Zhang, P Wu, X Ling, Q Wang, K Zhou, P Li… - Animals, 2022 - mdpi.com
Simple Summary Broilers provide a large amount of protein for human every year, in which
skeletal muscle contribute a major role. In recent years, circRNAs have been found to be …

Progressing neurobiological strategies against proteostasis failure: Challenges in neurodegeneration

A Amanullah, A Upadhyay, V Joshi, R Mishra… - Progress in …, 2017 - Elsevier
Proteins are ordered useful cellular entities, required for normal health and organism's
survival. The proteome is the absolute set of cellular expressed proteins, which regulates a …